Chinese Academy of Sciences

Jixia Wang

Zhiwei Wang

Xinmiao Liang

Chaoran Wang

Xiuli Zhang

Zhimou Guo

Changjian Wang

Yaopeng Zhao

Nana Du

Yanfang Liu

The disclosure relates to a 2-(2,2-diarylethyl)-cyclic amine derivative or salt, a synthesis method, an application and a composition thereof. Biological activity test shows that this kind of 2-(2,2-diarylethyl)-cyclic amine derivative has good M-receptor antagonistic activity; and can be used as an active component of drugs for the treatment of the diseases mediated or regulated by muscarinic receptors, such as asthma, chronic obstructive pulmonary disease (COPD), overactive bladder (OAB), bronchospasm with chronic obstructive pulmonary disease, visceral spasm, irritable bowel syndrome, Parkinson's disease, depression or anxiety, schizophrenia and related mental diseases.

2-(2,2-diarylethyl)-cyclic amine derivative or salt, synthesis method, application and composition thereof

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Liaoning, China

Jixia Wang