Amgen Inc.

Amgen Sf, LLC

Teon Therapeutics, Inc.

Tularik Limited

Jiwen Liu

Julio Cesar Medina

Yingcai Wang

Liusheng Zhu

Jonathan B Houze

Zhihua Ma

Zice Fu

An-Rong Li

Michael J Schmitt

Michael G Johnson

Rajiv Sharma

Wang Shen

Paul John Dransfield

Jinqian Liu

SuJen Lai

Ming Yu

Sean P Brown

Marc Vimolratana

XianYun Jiao

Xiaohui Du

Xiaoqi Chen

Jeffrey Thomas Mihalic

Vatee Pattaropong

Hilary Plake Beck

Jason A Duquette

Jeffrey Deignan

Darin J Gustin

Alan X Huang

Todd J Kohn

Andrew P Marcus

Elfatih O Elzein

Jian Luo

Zhongyu Wang

Jeffrey D Reagan

Michelle Akerman

Wei Qiu

Ying Sun

Lawrence R McGee

Frank Kayser

Daqing Sun

Xuelei Yan

Dustin L McMinn

David John Kopecky

Yosup Rew

Jonathan Dante Low

Felix Gonzalez Lopez De Turiso

Michael D Bartberger

Brian M Fox

Xiaodong Wang

John Eksterowicz

Brian Stuart Lucas

Steven H Olson

Ana Zurisadai Gonzalez Buenrostro

Richard V Connors

Julie Anne Heath

Zhihong Li

Joel McIntosh

Jian Zhang

Jiasheng Fu

Yihong Li

Yongli Su

Michael W Gribble, Jr

Xin Huang

Jiang Zhu

Benjamin Fisher

Philip M Roveto

Philippe Bergeron

Stephen J Shuttleworth

Daniel C H Lin

Xuemei Wang

Qingge Xu

Xi Alan Huang

H Lucy Tang

Matthew Irvine Brown

Bei Shan

Alan Martin Allgeier

Leping Li

Joseph F Payack

Feng Xu

Gayathri Swaminath

Sarah Lively

Jie Zhang

YuMei Xiong

Xian Yun Jiao

Thomas Storz

Serena T Cutler

Mark Grillo

Jerry A Murry

Margrit Schwarz

Yong-Jae Kim

Kevin Lustig

Hirohiko Hasegawa

Qiong Cao

Jacqueline E Milne

Janan Jona

Daniel Lin

Li Yang

Disclosed herein are compounds, compositions, and methods for modulating the Cannabinoid receptor 2 (CB2) with the compounds and compositions disclosed herein. Also described are methods of treating diseases or conditions that are mediated by the action of Cannabinoid receptor 2 (CB2) or that we benefit from modulating the Cannabinoid receptor 2 (CB2).

Cannabinoid receptor type 2 (CB2) modulators and uses thereof

Disclosed herein are compounds of Formula (III), compositions and formulations thereof,  and methods for modulating the A2adenosine receptor for treatment of Aadenosine receptor mediated diseases or conditions.

Adenosine receptor antagonists and uses thereof

The present invention provides MDM2 inhibitor compounds of Formula I, 

Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I&#x2032;B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Spirocyclic GPR40 modulators

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Phenyl acetic acid derivatives

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Substituted biphenyl GPR40 modulators

Heterocyclic GPR40 modulators

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune-related diseases and conditions are provided herein. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Compounds and methods useful for treating asthma and allergic inflammation

Compounds are provided having the formula: wherein variables R, R, R, R, R, A, A, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Benzo-fused compounds for use in treating metabolic disorders

Growing community of inventors

Foster City, CA, United States of America

Jiwen Liu