Asymchem Life Science (Tianjin) Co., Ltd

Asymchem Laboratories (Tianjin) Co., Ltd.

Jilin Asymchem Laboratories Co., Ltd.

Asymchem Laboratories (Fuxin) Co., Ltd.

Tianjin Asymchem Pharmaceutical Co., Ltd.

Other

Asymchem Life Science Co., Ltd.

Jiuyuan Li

Hao Hong

Gage James

Litao Shen

Changming Dong

Xin Hui Zhang

Lei Zhang

James Gage

Chaoyong Chen

Lina Guo

Changfeng Li

Hongying Tian

Gaochao Huang

The present invention relates to a preparation method for a chiral intermediate for use in statins, acquired with chloroacetic acid and benzyl alcohol as starting materials via a series of reactions, namely etherification, condensation, substitution, and asymmetric reduction. The preparation method provided in the present invention has a novel route of synthesis, allows an intermediate compound to be introduced conveniently into the chiral center of a glycol via enzyme reduction, and not only is low in costs, but also is reliable in quality. The route of synthesis provided in the present invention uses raw materials of low costs, has an easy to operate process, and provides a final product of great purity and high yield.

Preparation method for chiral intermediate for use in statins

A polymer containing a carboxyl group, a preparation method and an application thereof, a supported catalyst and a preparation method thereof and preparation methods of penem antibiotic intermediate are disclosed. The polymer has high rigidity and hardness, thus the mechanical properties of the polymer is effectively improved. Meanwhile, in the polymer, the carboxyl group is used as a main functional group, and is used as a carrier to prepare, by means of a coordination reaction between the carboxyl group and a heavy metal, a supported metal catalyst which has better connection stability between the metal and the polymer. The above two factors can improve the stability of the supported metal catalyst, such that the catalyst can be recycled without losing the catalytic activity. Meanwhile, loss of a heavy metal active ingredient and production cost can be reduced.

Polymer containing carboxyl group, preparation method and application thereof, supported catalyst and preparation methods thereof and preparation methods of penem antibiotic intermediate

A method for preparing nilotinib includes the following steps: performing an aminocarbonylation reaction on a compound A and 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl) aniline to obtain an amination product; and performing deprotection treatment of an R group on the amination product to obtain the nilotinib, wherein the compound A has a structure shown in formula I, and in formula I, an R group is selected from benzyl, &#x2014;COCF, &#x2014;CHO or &#x2014;COR', where an R&#x2032; group is C&#x2dc;Calkyl, C&#x2dc;Calkoxy ethyl or C&#x2dc;Caralkyl. 

Method for preparing nilotinib

Provided are an intermediate compound for preparing rosuvastatin calcium and a preparation method of the rosuvastatin calcium. The method comprises: using the foregoing intermediate compound as a raw material, and subjecting the raw material to a step of Wittig reaction, a step of protecting group removal and hydrolysis and a step of calcium salt formation, so as to obtain the rosuvastatin calcium. The product, which is prepared from the intermediate compound, can be substantially enhanced in stereoselectivity and also notably improved in purity and yield; in addition, the method for preparing rosuvastatin calcium from the intermediate compound is simple, convenient and low in cost. 

Intermediate compound for preparing rosuvastatin calcium and method for preparing rosuvastatin calcium therefrom

Growing community of inventors

Tianjin, China

Jiuyuan Li