St. Jude Children's Research Hospital

The University of Tennessee Research Foundation

Coa Therapeutics, Inc.

Jiuyu Liu

Richard Edward Lee

Julian G Hurdle

Charles O Rock

Mi Kyung Yun

Suzanne Jackowski

Chitra Subramanian

Lalit Kumar Sharma

Jianjun Qi

Bernd Meibohm

Vnr Pavan Kumar Vaddady

Rakesh

Robert J Zamboni

Zhong Zheng

T Jagadeeswar Reddy

Anne V Edwards

Jason W Rosch

Rajendra P Tangallapally

David F Bruhn

Samanthi L Waidyarachchi

Pavan Vaddady

Rakesh,

Pavan Kumar Vaddady

The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Methods of treating disorders associated with castor

The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Small molecule modulators of pantothenate kinases

The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.

Aryl substituted aminomethyl spectinomycin analogs as antibacterial agents

Novel 3'-deoxy-3&#x2032;-acylaminospectinomycin compounds are described. Also described are methods of using the 3&#x2032;-deoxy-3-acylaminospectinomycin compounds and other spectinomycin analogs in treating tuberculosis and in treating microbial infections.

Spectinamides as anti-tuberculosis agents

Growing community of inventors

Bartlett, TN, United States of America

Jiuyu Liu