Genentech, Inc.

Merck Sharp + Dohme Corp.

Xenon Pharmaceuticals Inc.

Eccogene (Shanghai) Co., Ltd.

Eccogene Inc.

Jiuxiang Zhu

Nigel J Liverton

Yongxin Han

Daniel P Sutherlin

Christoph Martin Dehnhardt

Shaoyi Sun

Brian Salvatore Safina

Sultan Chowdhury

Shawn J Stachel

Michael T Rudd

Daniel Fred Ortwine

Qi Jia

Alla Yurevna Zenova

Paul Tempest

Ivan William Hemeon

Zhaoyang Meng

David Jonathan Bennett

Jun M Li

Zhiguo Liu

Edward J Brnardic

Jenny Wai

Xuewang Xu

Andrew D White

Thilo Focken

Michael Edward Grimwood

Jingye Zhou

Michael Scott Wilson

Jean-Christophe Andrez

Paul Robert Bichler

Bin Zhu

Shannon Marie Decker

Mingwei Zheng

Tao Sheng

Chien-An Chen

Abid Hasan

Wei Gong

Chuanman Huang

Jun Li

The application relates to a compound of Formula (I′) or (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I') or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.

Thyroid hormone receptor agonists and use thereof

The application relates to a compound of Formula (I') or (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I&#x2032;) or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.

In its many embodiments, the present invention provides certain substituted aryl and heteroaryl ether compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, R, R, R, L, R, L, Q, and Rare as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-&#x3b2; receptor (LXR&#x3b2;) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease. 

Aryl and heteroaryl ether derivatives as liver X receptor beta agonists, compositions, and their use

In its many embodiments, the present invention provides certain substituted N-aryl and N-heteroaryl piperidine compounds of the Formula (I): 

N-aryl and N-heteroaryl piperidine derivatives as liver X receptor beta agonists, compositions, and their use

In its many embodiments, the present invention provides certain piperidine compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, Y, R, R, R, L, R, L, Q, and Rare as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-&#x3b2; receptor (LXR&#x3b2;) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease. 

Piperidine derivatives as liver X receptor beta agonists, compositions, and their use

The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Growing community of inventors

Shanghai, China

Jiuxiang Zhu