Monsanto Company

Feder, Joseph

Harakas, Nicholaos K.

Schaumann, Jon P.

Olander, Jitka V.

Joseph Feder

Jitka V. Olander

Daniel T. Connolly

Jitka V Olander

Jon P Schaumann

Nicholaos K Harakas

Steven P Adams

William R Tolbert

Daniel T Connolly

Charles Lewis, Jr

Nicholaos K Hrakas

A method of producing antibodies against vascular permeability factor (VPF) is disclosed which comprises immunizing a host animal with a peptide having an amino acid sequence as follows: ##STR1## or a fragment of said peptide containing an antigenic determinant of VPF.

Antibodies to VPF

A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.

Monoclonal antibody specific for human colon fibroblast-derived t-PA

Monoclonal antibody specific for human colon fibroblast-derived T-PA

Monoclonal antibodies are isolated from spent culture medium of the in vitro growth of hybridoma cells by treating said spent cell culture medium or a concentrate thereof with a water-insoluble, cross-linked polyelectrolyte copolymer.

Method of isolating monoclonal antibodies from hybridoma cultures

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University City, MO, United States of America

Jitka V Olander