US Government As Represented by the Secretary of the Army

Banyan Biomarkers, Inc.

Jitendra Ramanlal Dave

Ronald L Hayes

Frank Casper Tortella

Zhiqun Zhang

Kevin Ka-Wang Wang

Ming-Cheng Liu

Mark W Brown

Larry R Holmes, Jr

Xi-Chun May Lu

Anthony Joseph Williams

Zachary J Larimore

Mark F Arnold

Deborah A Shear

Kara E Schmid

Lai Yee Leung

Zhiyong Chen

Changping Yao

Zhilin Liao

Xi-Chun May

Ka-Wang Kevin Wang

Jay E Bartlett

Mark P Easterday

Andrea Mountney

Processes and materials are provided for the detection, diagnosis, or determination of the severity of a neurological injury or condition, including traumatic brain injury, multiple-organ injury, stroke, Alzeimer's disease, Parkinson disease and Chronic Traumatic Encephalopathy (CTE). The processes and materials include biomarkers detected or measured in a biological sample such as whole blood, serum, plasma, or CSF. Such biomarkers include Tau and GFAP proteins, their proteolytic breakdown products, brain specific or enriched micro-RNA, and brain specific or enriched protein directed autoantibodies. The processes and materials are operable to detect the presence of absence of acute, subacute or chronic brain injuries and predict outcome for the brain injury.

Micro-RNA, autoantibody and protein markers for diagnosis of neuronal injury

An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.

Device and method for inducing brain injury in animal test subjects

A diagnostic tool and method of diagnosing brain injury and brain injury type (traumatic vs. ischemic) by detecting the level of expression of endothelial monocyte-activating polypeptide II (EMAP-II) and comparing to a control. An increase of EMAP-II indicates the presence of traumatic brain injury and a decrease of EMAP-II indicates the presence of ischemic brain injury. Detection of EMAP-II can be done in brain tissue, biofluids such as cerebrospinal fluid or blood (including plasma and serum).

Endothelial-monocyte activating polypeptide II, a biomarker for use in diagnosis of brain injury

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Gaithersburg, MD, United States of America

Jitendra Ramanlal Dave