The Scripps Research Institute

University of Florida Research Foundation Inc

Jitendra K Mishra

William R Roush

Thomas D Bannister

Andy Tsai

John L Cleveland

Jun Yong Choi

Reji Nair

Andy S Tsai

The invention provides compounds of formulae A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.

Heterocyclic inhibitors of monocarboxylate transporters

The invention provides heterocyclic compounds of formula A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.

The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.

Heterocyclic inhibitors of monocarboxylate transporter

Growing community of inventors

Memphis, TN, United States of America

Jitendra K Mishra