Nippon Suisan Kaisha, Ltd.

National Center of Neurology and Psychiatry

Nissui Corporation

Nippon Sulsan Kaisha, Ltd.

Jiro Takeo

Shinya Yamashita

Takaaki Okita

Shuji Jinno

Naomi Ohtsuka

Junichiro Hata

Hiroyuki Kawahara

Yasuhiro Fukuda

Keiji Wada

Hiroyuki Onuki

Yasuyo Kogure

Daisuke Yamada

Seizo Sato

Masayuki Sekiguchi

Yoshiyuki Chiba

Shoichi Yamada

Hiroko Miyahara

Akihisa Abe

Hiroshi Sakaue

Rie Tsutsumi

Wakako Seki

Fumie Iwata

[Problem] To provide a composition for external skin use that has anti-inflammatory and antiallergic activity, and is very safe. [Solution] A composition for external skin use for inflammatory diseases contains dihomo-gamma-linolenic acid (DGLA) as the active ingredient thereof. It is preferable for the DGLA to be present as a glyceride, a phospholipid, or an alkyl ester. The amount of DGLA contained in the composition for external use is 0.1-50 wt %.

Composition for external use on skin for inflammatory diseases

The present invention provides a composition for improving vascular endothelial function, comprising: an ingredient selected from a monounsaturated fatty acid having 20 carbon atoms or more, a salt thereof, and an ester thereof as an active ingredient, in which the ratio of the monounsaturated fatty acid having 20 carbon atoms or more to the total fatty acids in the composition is 10 wt % or greater. The present invention also provides a composition for improving sleep, comprising an ingredient selected from a monounsaturated fatty acid having 20 carbon atoms or more, a salt thereof, and an ester thereof as an active ingredient.

Composition for improving vascular endothelial function

A compound derived from the culture product of an actinomycete and having an antitumor activity is provided. Provided is a compound represented by any one of formulas (I), (II) and (III) or an optical isomer thereof or a pharmaceutically acceptable salt thereof which can be isolated from the culture fluid of an actinomycete which belongs to the genus, wherein R, R, Rand Reach independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or a double bond by which Rand Ror Rand Rare bonded; R, R, Rand Reach independently represent a methyl group or a hydroxymethyl group; and Rrepresents a hydrogen atom or a hydroxyl group.

Tricyclic condensed heterocyclic compound, process of producing same, and use thereof

[Problem] Provision of a composition for external use on skin that is safe to use and has an anti-inflammatory and anti-allergic actions. [Solution] A composition for external use on skin in the treatment of inflammatory disease which comprises dihomo-&#x3b3;-linolenic acid (DGLA) as an active ingredient. The DGLA is preferably contained as a glyceride, a phospholipid, or an alkyl ester. The composition for external use contains DGLA in an amount of 0.1-50 wt %.

The present invention provides new methods of intervention for anxiety associated disorders, in particular, trauma-derived disorders such as PTSD, and therapeutic or prophylactic agents for anxiety associated disorders that can be used as foods, beverages, and dietary supplements, for example, and which contain as an active ingredient n-3 polyunsaturated fatty acids contained in krill oil or fish oil, for example. The present invention further provides methods for alleviating fear memory or methods for preventing its formation by adjusting the proportion of n-3 polyunsaturated fatty acids to n-6 polyunsaturated fatty acids as ingested.

Method for alleviating fear memory

Tricyclic fused heterocycle compounds, process for preparing the same and use thereof

The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient.

Tracheal smooth muscle relaxants

Tracheal smooth muscle relaxant

Glutamic acid receptor agonist

Growing community of inventors

Tokyo, Japan

Jiro Takeo