Fujisawa Pharmaceutical Company, Ltd.

Jiro Goto

Kazuo Sakane

Tsutomu Toyonaka Teraji

Takashi Kamiya

Yoshiharu Nakai

Hideaki Yamanaka

Shinya Okuda

Takeshi Terasawa

Yoshiki Yoshida

Keiji Hemmi

Compounds of the formula: ##STR1## wherein R is a group of the formula: ##STR2## in which R.sup.3 and R.sup.4 are each lower alkyl or R.sup.3 and R.sup.4 are linked together to form C.sub.3 -C.sub.6 alkylene, A is lower alkylene, and R.sup.5 is hydroxy or a protected hydroxy group; or a group of the formula: ##STR3## in which R.sup.6 is lower alkyl, R.sup.7 and R.sup.8 are each hydroxy or a protected hydroxy group, and Y is N or CH, and salts thereof are intermediates for cephem compounds which show antimicrobial activities and which are useful in the treatment of microbial infections.

Intermediates for cephem compounds

Cephem compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,

Cephem compounds

Cephem compounds having the following formula are disclosed: ##STR1## R.sup.1 =amino or protected amino R.sup.2 =an organic group ##STR2## R.sup.6 =lower alkyl R.sup.7, R.sup.8 .dbd.OH or protected OH

The invention relates to intermediates useful in the preparation of antimicrobial compounds, the intermediates being of the formula: ##STR1## wherein R.sup.A is --SCN or --S.sup..sym. (R.sup.3).sub.2, wherein

The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is phosphono, dihalophosphoryl, di(lower) alkoxyphosphoryl, O-lower alkylphosphono, diaminophosphoryl, (amino) (hydroxy) phosphoryl or (lower alkoxy) (morpholino) phosphoryl,

Cephem intermediates

A novel compound, useful as an intermediate in the production of compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sub.a.sup.1 is hydrogen, amino or a protected amino group,

Pyridinyl and pyrimidinyl derivatives

The cephalosporin intermediate 2-(5-amino-1,2,4, thiadiazol-3yl)glyoxylic acid has been prepared.

Cephem and cepham compounds and processes for preparation thereof

The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is phosphono, dihalophosphoryl, di(lower) alkoxyphosphoryl, O-lower alkylphosphono, diaminophosphoryl, (anino) (hydroxy) phosphoryl or (lower alkoxy) (morpholino) phosphoryl,

The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or lower alkanoylamino,

The invention relates to cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;

This invention relates to cephem compounds of high antimicrobial activity of the formula ##STR1## wherein R.sup.1 is amino or a protected amino group;

This invention relates to thiadiazolyl compounds useful as intermediates in the preparation of novel cephem compounds of high antimicrobial activity.

2-Substituted oxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetic acids

This invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;

This invention relates to novel cephem compounds of high antimicrobial activity, to processes for preparation of said compounds, and to pharmaceutical compositions comprising said compounds, the novel cephem compounds being of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;

This invention relates to novel cephem compounds of high antimicrobial activity of the formula ##STR1## wherein R.sup.1 is amino or a protected amino,

Growing community of inventors

Suita, Japan

Jiro Goto