Spofa, Spojene Podniky Pro

Spojene Podniky Pro Zdravotnickou Vyrobu

Jiri Vanzura

Evzen Kasafirek

Ivan Krejci

Antonin Sturc

Jiri Krepelka

Antonin Dlabac

Milan Pesak

Alena Roubalova

Miroslav Rybak

Arnost Pospisil

Vaclav Plaisner

Jirj Kohout

Libuse Korbova

Michal Bartik

Jirina Cizkova

Evzen Krepela

A cell-protective composition for preventing or treating of a peptic ulcer due to topical endogenous lesion of gastric or duodenal mucous membrane comprises as a physiologically active component the cyclo-(1-alanyl-amino-1-cyclopentanecarbonyl)cyclodipeptide. The subject composition is designated for administration by oral or parenteral route. It is substantially non-toxic and well tolerated, and acts beneficially, even at low dosage level.

Cell-protective composition for preventing or treating of peptic ulcer

Peptide ester and amide derivatives of the general formula I: ##STR1## in which X is H or an acyl, A and B are structurally defined amino acid residues, n is an integer of from 1 to 3, R.sup.1 is H or a lower alkyl and either R.sup.2 or C is a defined optionally modified amino acid residue and the other is a lower alkoxyl, an amino group or a direct chemical bond, are converted under physiologic conditions, by enzymic hydrolysis in pathologically altered tissues and subsequent spontaneous cyclization, into pharmacodynamically active spirocyclic peptide derivatives of the general formula III: ##STR2## in which R.sup.3 and R.sup.4 are H atoms, optionally substituted alkyl groups or jointly an aliphatic chain forming preferably a 2,5- piperazinedione ring, and hence can act as pro-farmaca (drug precursors) of prolonged biological effect.

Peptide derivatives and processes for their preparation

Growing community of inventors

Hradec Kralove, Czechia

Jiri Vanzura