Ustav Makromolekularni Chemie Av Cr, V.v.i.

Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Univerzita Karlova V Praze, Prirodovedecka Fakulta

Univerzita Karlova

Mikrobiologicky Ustav Av Cr, V.v.i.

Jiri Strohalm

Karel Ulbrich

Jan Konvalinka

Pavel Sacha

Jiri Schimer

Vladimir Subr

Tomas Knedlik

Pavel Majer

Petr Cigler

Blanka Rihova

Tomas Etrych

Vaclav Navratil

Petr Chytil

Frantisek Sedlak

Jan Tykvart

A macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells.

Macromolecular conjugates for visualization and separation of proteins and cells

Synthetic macromolecular conjugate for selective interaction with proteins has a synthetic copolymer, and at least one binding group and at least one further group selected from an affinity tag and an imaging probe, and at least one binding group and at least one further group being bound via covalent bond to the synthetic copolymer. The macromolecular conjugate is suitable in particular for identification, visualization, quantification or isolation of proteins and/or cells.

Macromolecular conjugates for isolation, immobilization and visualization of proteins

The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.

Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours

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Prague, Czechia

Jiri Strohalm