Other

Purdue Research Foundation

Jiri Adamec

Fred E Regnier

JinHee Kim

Richard P Zoltek

Wenchu Yang

Timothy E Woenker

Wen-Chu Yang

The present invention comprises methods for determining the presence, amount, or concentration of analytes of interest including Vitamin D and other secosteroids from biological samples, through derivatization, with improved speed and ease of analysis and improved sensitivity to mass spectrometry. In a preferred embodiment, the present invention comprises methods for determining the presence, amount, or concentration of analytes of interest, including Vitamin D and other secosteroids from whole human blood, through derivatization, and using a plasma collection device to facilitate collection, separation, and preparation of the sample for derivatization and analysis.

Method for determining derivatized analytes in a separated biological fluid

Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distinct forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.

Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules

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Denton, NE, United States of America

Jiri Adamec