The Johns Hopkins University

Other

Jinyuan Zhou

Paul Arthur Bottomley

Yi Zhang

Peter C M Van Zijl

A method of spatially imaging a nuclear magnetic resonance (NMR)parameter whose measurement requires the acquisition of spatially localized NMR signals in a sample includes placing the sample in an MRI apparatus with a plurality of MRI detectors each having a spatial sensitivity map; and applying MRI sequences adjusted to be sensitive to the NMR parameter. At least one of the MRI sequences is adjusted so as to substantially fully sample an image k-space of the sample. The remainder of the MRI sequences is adjusted to under-sample the image k-space. The method further includes acquiring image k-space NMR signal datasets; estimating a sensitivity map of each of the MRI detectors using a strategy to suppress unfolding artefacts; and applying the estimated sensitivity maps to at least one of the image k-space NMR signal data sets to reconstruct a spatial image of NMR signals that are sensitive to the NMR parameter.

Method of fast imaging of NMR parameters with variably-accelerated sensitivity encoding

An NMR method and system for acquiring and reconstructing a value of an NMR parameter spatially localized to a compartment of interest including performing a first MM of a portion of a sample with a first MRI pulse sequence using the NMR system and using a set of k-space spatial encoding gradients or coil sensitivity encoding maps to obtain a first magnetic resonance image to identify a compartment of interest; generating a second MRI pulse sequence that encodes the NMR parameter with a subset of the set of k-space spatial encoding gradients or the coil sensitivity encoding maps; applying the second MRI pulse sequence using the NMR system to acquire spatial information relating to the NMR parameter from the compartment of interest; segmenting the first magnetic resonance image into a plurality of compartments that includes the compartment of interest; and reconstructing a value of the NMR parameter in the compartment.

System and method of obtaining spatially-encoded NMR parameters from arbitrarily-shaped compartments and linear algebraic modeling

A magnetic resonance method for imaging blood volume in parenchyma via magnetic transfer (MT) includes: determining a MT effect of parenchyma; determining a MT effect of tissue; and quantifying the parenchymal blood volume using the difference between the MT effect of parenchyma and the MT effect of tissue. In one embodiment, the parenchymal blood volume is quantified through the following: MTR=MTR(1&#x2212;BV/V), where MTRis the magnetization transfer ratio of parenchyma, MTRis the magnetization transfer ratio of tissue, BV is the blood volume, and Vis a total parenchymal water volume.

Quantifying blood volume using magnetization transfer magnetic resonance imaging

Featured is an MRI/NMR methodology or process to detect amide protons of endogenous mobile proteins and peptides via the water signal. Such methods and processes can be used for the purposes of detection of pH effects and labile amide proton content of mobile proteins/peptides or content changes thereto using MRI Also featured are methods whereby assessment of determined pH effects and amide proton content or content changes and related mobile protein and/or peptide content or content changes can be used in connection with diagnosis, program and treatment of brain related disorders and diseases, cardiac disorders and diseases, and cancer and to use such methods for monitoring, detecting and assessing protein and peptide content in vivo and pathologically for any of a number of diseases or disorders of a human body, including but not limited to cancers, ischemia, Alzheimers and Parkinsons.

MAGNETIC RESONANCE METHOD FOR ASSESING AMIDE PROTON TRANSFER EFFECTS BETWEEN AMIDE PROTONS OF ENDOGENOUS MOBILE PROTEINS AND PEPTIDES AND TISSUE WATER IN SITU AND ITS USE FOR IMAGING PH AND MOBILE PROTEIN/PEPTIDE CONTENT

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Cockeysville, MD, United States of America

Jinyuan Zhou