Ge Healthcare Bio-sciences Ab

Cytiva Bioprocess R&d Ab

Ge Healthcare Bioprocess R&d Ab

Ge Healthcare Bioprocess R&d

Jinyu Zou

Gustav Jose Rodrigo

Martin Hall

Per-Mikael Aberg

Sture Larsson

Andreas Muranyi

Mats Ander

Ronnie Palmgren

Andreas Axen

Enrique Napoleon Carredano

Mathias Alterman

Mattias Algotsson

Johan William Ohman

Anna Grönberg

Therese Graner

Jimmy Hedin Dahlstrom

Ylva Laurin

Anneli Jorsback

Miles W Burrows

Jimmy Hedin Dahlström

Johan Ohman

Gustav Rodrigo

Per-Mikael ÅBerg

The present invention relates to a chromatography ligand, which comprises Domain C fromprotein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.

Chromatography ligand comprising domain c fromprotein a for antibody isolation

The present invention relates to a chromatography ligand, which comprises Domain C fromprotein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIF) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.

Chromatography ligand comprising domain C fromprotein A for antibody isolation

The present invention relates to the field of chromatography and more specifically to producing protein affinity chromatography resins comprising affinity ligands based on a N-terminal fragment of a split intein, such as DnaE from, as well as methods for using the same. The N-terminal fragments are produced in inclusion bodies in bacterial cells.

Chromatography resin, production and use thereof

The invention discloses a cellulose or glass fiber paper for preservation of biological samples, which comprises 4-30 wt % of a hydrophilic branched carbohydrate polymer. It also discloses a method for preservation of biological samples by applying and drying them on the paper.

Sample preservation method and sample preservation substrate

The present invention relates to a chromatography ligand, which comprises Domain C fromprotein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.

[object Object]

The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula and its corresponding enol-form, wherein X represents O, S, or NH; Rrepresents H, Calkyl, Calkoxy, Calkoxy-Calkyl, Ar, &#x2014;C(O)NHR, &#x2014;C(O)&#x2014;Ror halo; Rrepresents H, Calkyl or halo; Rrepresents H, Calkyl, Calkoxy, Calkoxy-Calkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.

[1, 2, 4] Triazolo [1, 5-A] pyrimidine derivatives as chromatographic adsorbent for the selective adsorption of IGG

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Uppsala, Sweden

Jinyu Zou