Dracen Pharmaceuticals, Inc.

Jinxiao Chu

Pavel Majer

Yiyang Shao

Jon Philip Lawson

Jinchao Weng

Robert Christian Wild

Ivan Šnajdr

Martin Hadzima

Lukáš Tenora

The present disclosure provides methods of preparing a compound of Formula (I): wherein R, R, and Rare as defined as set forth in the application. In one embodiment, a compound of Formula (I) is prepared in >95% chemical purity and >95% enantiomeric excess.

Method of preparing a DON prodrug from L-glutamic acid

The present disclosure provides a method of preparing a compound of Formula I, wherein Ris C-Calkyl; Ris C1-C4 alkyl; and Ris selected from the group consisting of C-Calkyl, (aryl)alkyl, and (heteroaryl)alkyl in &#x3e;95% chemical purity and &#x3e;95% enantiomeric excess.

Method of preparing a DON prodrug from L-pyroglutamic acid

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Beijing, China

Jinxiao Chu