Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd.

Jinxiang Zeng

Juan Yu

Shuhui Chen

Jinming Huang

Tingting Yin

Limei Yang

Jian Li

Wentao Wu

Zhixiang Li

Zhifei Fu

Miaorong Luo

Fei Hong

Jian Qin

Jinxia Lin

Shicong Wang

Huijun Yuan

Disclosed is a method for preparing a pyrrolidinyl urea derivative, which acts as a TrkA inhibitor, and further disclosed are an intermediate compound of a compound of formula (I) and a preparation method therefor.

Method for preparing pyrrolidinyl urea derivative

Provided are preparation methods for the chemical compound represented by formula (I) and an intermediate thereof. 

Pyrazine-2(1H)-ketone compound preparation method

Disclosed is a total flavonoids extract ofKitam., containing 80%-85% of rutin by weight percent content. The results of pharmacological experiments show that the extract can lower the activity of xanthine oxidase in the liver of a hyperuricemia model mouse and reduce the synthesis of uric acid to a certain degree and has a certain uric acid-lowering effect, and can be used as a potential drug for treating hyperuricemia or gout. The method for preparing the total flavonoids extract ofKitam. comprises: after an extraction step, selecting a complex enzyme composed of enzymes with a specific composition and a specific ratio for enzymolosis, and further carrying out the step of extracting and concentrating with macroporous resin and isolating and purifying with macroporous resin, so that the HPLC purity of rutin in the resulting total flavonoids extract ofKitam. reaches 80%-85%.

Total flavonoids extract ofKitam., preparation method therefor and use thereof for treating hyperuricemia

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Fujian, China

Jinxiang Zeng