University of California

Yonsei University

Jinwoo Cheon

Jae-Hyun Lee

Hsian-Rong Tseng

Jeffrey I Zink

Monty Liong

Kuan-Ju Chen

Young-wook Jun

Jung-tak Jang

Courtney R Thomas

Sarah Ann Henscheid

Daniel P Ferris

Seung-hyun Noh

A method for controlled delivery of a substance into a body includes administering a plurality of containment vessels into the body, in which each of the plurality of containment vessels includes a quantity of the substance loaded therein prior to the administering; and providing a time-varying magnetic field such that the plurality of containment vessels are exposed thereto to cause a release of at least a portion of the substance from the plurality of containment vessels. Each of the plurality of containment vessels has an average outer diameter less than about 1 &#x3bc;m.

Method of controlled delivery using sub-micron-scale machines

The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of 'zinc-containing metal oxide nanoparticle&#x2014;biologically/chemically active material' in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.

Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles

Growing community of inventors

Seoul, South Korea

Jinwoo Cheon