Js Innopharm (shanghai) Ltd.

Changzhou Jiekai Pharmatech Co., Ltd.

Akzo Nobel Coatings International B.v.

Js Innopharm (shanhai) Ltd.

Js Innomed Holdings Ltd.

Js Innopharm Ltd.

Jintao Zhang

Shanzhong Jian

Wen Kang Xu

Qun Li

Quanhai Liu

Ao Qiong Li

Junbiao Lu

Minyu Liu

Xiaoling Huang

Yifang Deng

Pengxia Yu

Jihai Xu

Jin Hyun Kim

The present disclosure provides a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds. They are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof

Disclosed herein are compounds of formula I and/or a stereoisomer, stable isotopologue, and/or pharmaceutically acceptable salts thereof; and therapeutic uses of these compounds, which are inhibitors of tryptophan 2, 3-dioxygenase 2 (TDO2) and/or indoleamine 2, 3-dioxygenase 1 (IDO1), potentially useful in the treatment of diseases treatable, such as cancers. 

Heterocyclic compounds, compositions comprising heterocyclic compound, and methods of use thereof

The present disclosure relates to a 2K coating composition comprising a polysiloxane-modified polyurethane and a hardener, wherein the polysiloxane-modified polyurethane obtainable by a method comprising the following steps: a) subjecting a polyol to a reaction with an isocyanate-functional silane coupling agent to obtain a silane-grafted polyol, and b) subjecting the silane-grafted polyol to a condensation reaction with a hydroxyl-functional polysiloxane, to obtain the polysiloxane-modified polyurethane. The polysiloxane-modified polyurethane can be used in a coating composition to form a coating which has smooth feel, stain resistance and easy clean properties, particularly desired in the field of e.g. consumer electronics and automotive industry.

Coating composition comprising polysiloxane-modified polyurethane for soft-feel, stain resistant coatings

(I) Disclosed herein are compounds of formula I, and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds, which are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers, as well as pharmaceutical compositions, comprising a compound of formula I, and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 

Disclosed herein is a compound of formula (I) and/or a pharmaceutically acceptable salt thereof that can serve as Erk inhibitors. They are potentially useful in the treatment of diseases treatable by inhibition of Erk, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of formula I and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. 

Pyrazolo fused heterocyclic compounds as ERK inhibitors

Disclosed herein is a compound of formula I and/or a pharmaceutically acceptable salt thereof that can serve as Erk inhibitors: They are potentially useful in the treatment of diseases treatable by inhibition of Erk, such as cancers. Also disclosed herein is a pharmaceutical composition comprising a compound of formula I and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

Heterocyclic compounds as ERK inhibitors

Disclosed herein is a method of treating psoriasis involving the use of compound of formula I and/or a pharmaceutically acceptable salt thereof. 

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Naperville, IL, United States of America

Jintao Zhang