USA As Represented by Secretary of the Navy

Jinny Lin Liu

George P Anderson

Ellen R Goldman

Daniel Zabetakis

Banahalli R Ratna

Ronald J Tonucci

Marc P Raphael

James Peter Long

Thomas O'Shaughnessy

Carissa M Soto

Amy S Blum

Ronald W Rendell

Wu Ma

Michael A Bruckman

Thomas J Esparza

A number of single domain antibodies (sdAb, also known as nanobodies or VHH) were developed that bind nucleocapsid protein of the SARS-CoV-2 virus. They are useful for detecting the virus and could also find application in therapeutics.

Single domain antibodies to SARS-CoV-2 nucleocapsid protein

Described herein are nucleic acids encoding single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Chikungunya Virus (CHIKV).

Nucleic acids encoding single domain antibodies to chikungunya virus

Described herein are single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Chikungunya Virus (CHIKV).

Single domain antibodies to Chikungunya virus

Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.

Antibody and recombinant derivative for the detection of trinitrotoluene

Described herein is the development of recombinant single domain antibodies, also known as nanobodies, that may provide better therapeutic results or be useful for diagnostic applications of B-cell lymphomas, or in other applications where an antibody to CD20 may be useful.

Single domain antibodies that bind to human CD20

Genetic fusions of proteins, for example single-domain antibodies (sdAbs), with a positively-charged domain enhanced immobilization of active protein in a desired orientation.

Charged peptide appendage to facilitate oriented protein covalent immobilization

Protein scaffolds from tobacco mosaic virus coat protein modified to incorporate polyhistidine can bind to a metal or a dye while having improved self-assembly characteristics. The scaffold can take the form of tubes or disks, and can further be formed into dual plasmonic ring resonators. Such self-assembled structures provide useful optical properties.

Metamaterial optical elements self-assembled on protein scaffolds

This invention comprises a method for generating functional neural networks using neural progenitor cells on microelectrode arrays (MEAs). The method involves dissociating neural progenitor cells from an embryo, propagating the neural progenitor cells, passaging the neural progenitor cells and seeding the neural progenitor cells on MEAs to produce a functional neural network. The neural progenitor cells may be continuously passaged to propagate an endless supply of neural progenitor cells. The resultant passaged progenitor cell derived neural network MEA may be used to detect and/or quantify various biological or chemical toxins.

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Ellicott City, MD, United States of America

Jinny Lin Liu