Koninklijke Philips Corporation N.v.

University of Washington

Tsinghua University

Jinnan Wang

Chun Yuan

Peter Boernert

Huijun Chen

Raymond C Chan

Gert Wim 't Hooft

Christopher Stephen Hall

Peter Börnert

Maya Ella Barley

Luis Felipe Gutierrez

Adrien Emmanuel Desjardins

William Sean Kerwin

Vasily L Yarnykh

Michael Günter Helle

Niranjan Balu

Gert 'T Hooft

Gert Wim 'T Hooft

An imaging system () includes a subject support () that supports a subject in an examination region (). The imaging system further includes a detector () that detects a signal traversing the examination region, generating an output indicative of the examination region. The imaging system further includes a subject motion sensing system () that includes an optical system () that detects motion of the subject in the examination region and generates motion data indicative thereof. The imaging system further includes a console () that controls at least one of data acquisition or reconstruction based on the motion data.

Optical based subject motion detection in imaging systems

A system and method for adaptive imaging include a shape sensing system () coupled to an interventional device () to measure spatial characteristics of the interventional device in a subject. An image module () is configured to receive the spatial characteristics and generate one or more control signals in accordance with the spatial characteristics. An imaging device () is configured to image the subject in accordance with the control signals.

Adaptive imaging and frame rate optimizing based on real-time shape sensing of medical instruments

A medical system () and method () image a vessel wall automatically. A scout scan of a patient for localizing a target vessel of the patient is automatically performed () using magnetic resonance (MR). The scout scan is three-dimensional (3D) and isotropic. An MR data set of the scout scan is automatically reconstructed () into foot-to-head (FH), left-to-right (LR) and posterior-to-anterior (PA) projections. A3D imaging volume () encompassing the target vessel is automatically determined () from the projections, and a diagnostic scan of the 3D imaging volume () is performed () using MR.

Push-button vessel wall MRI with 3D scout scan

A phase sensitive inversion recovery (PSIR)-based MR imaging method of at least two chemical species having different MR spectra enables distinction between myocardial scar and myocardial triglyceride deposition. The method includes the steps of: a) generating echo signals at two or more different echo times by subjecting an object () positioned in the examination volume of a MR device () to an imaging sequence of RF pulses and switched magnetic field gradients, which imaging sequence is an inversion recovery sequence including an inversion RF pulse followed by an excitation RF pulse after an inversion recovery time; b) acquiring the echo signals; c) separating signal contributions of the at least two chemical species to the acquired echo signals; and d) reconstructing a phase-sensitive MR image () from the signal contributions of at least one of the chemical species.

Phase sensitive inversion recovery MRI with water/fat separation

A magnetic resonance system (), and corresponding method, image a subject using a conversion-free interleaved black and bright blood imaging (cfIBBI) sequence. A MR scanner () is controlled to perform a plurality of repetitions of a black blood imaging sequence (). The black blood imaging sequence () includes a tissue nulling sub-sequence followed by a black blood acquisition sub-sequence () performed a time interval (TI) after the tissue nulling sub-sequence. The MR scanner () is further controlled to, between successive repetitions of the black blood imaging sequence (), perform a bright blood imaging sequence () including the tissue nulling sub-sequence followed by a bright blood acquisition sub-sequence () performed the time interval (TI) after the tissue nulling sub-sequence. The time intervals (TI) of the black blood imaging sequence () and the bright blood imaging sequence () are of the same duration.

Interleaved black and bright blood imaging for interleaved dynamic contrast enhanced magnetic resonance imaging

A black blood magnetic resonance imaging sequence is performed using a magnetic resonance scanner. The sequence includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice-selective radio frequency excitation pulse after applying the spoiler gradient; and performing a magnetic resonance readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation. The readout acquires magnetic resonance imaging data having blood signal suppression in the region excited by the slice-selective radio frequency excitation pulse. The magnetic resonance imaging data is suitably reconstructed to generate a black blood image that may be displayed.

Black blood MRI using a stimulated echo pulse sequence with flow sensitization gradients

Methods and systems for using magnetic resonance (MR) imaging include obtaining a T1-weighted MR image and a proton-density (PD) weighted MR image from a dual-image acquisition following an inversion-recovery (IR) pulse. The T1-weighted and PD-weighted images are used to obtain a polarity function describing a positive or negative polarity at individual voxels, which is used to reconstruct a polarity-enhanced PD-weighted image from the PD-weighted image. The polarity-enhanced PD-weighted image can be used for assessing at least plaque burden and juxtaluminal calcification (JCA).

Dual contrast vessel wall MRI using phase sensitive polarity maps

Interleaved black/bright imaging (IBBI) is performed using a magnetic resonance (MR) scanner wherein the black blood module of the IBBI includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice selective radio frequency excitation pulse after applying the spoiler gradient; and performing a MR readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation wherein the readout acquires MR imaging data having blood signal suppression in the region excited by the slice selective radio frequency excitation pulse. The MR imaging data having blood signal suppression is reconstructed to generate black blood images, and MR imaging data generated by bright blood modules of the IBBI is reconstructed to generate bright blood images.

Interleaved black and bright blood dynamic contrast enhanced (DCE) MRI

Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse (). MR signals are acquired at an inversion time (TI) after the IR radio frequency pulse. TI is selected such that a first tissue of interest (e.g., blood) exhibits negative magnetism excited by the IR radio frequency pulse and a second tissue (e.g., intraplaque hemorrhage tissue) exhibits positive magnetism excited by the IR radio frequency pulse. The acquired magnetic resonance signals are reconstructed to generate spatial pixels or voxels wherein positive pixel or voxel values indicate spatial locations of positive magnetism and negative pixel or voxel values indicates spatial locations of negative magnetism. A first image () representative of the first tissue is generated from spatial pixels or voxels having negative signal intensities, and a second image () representative of the second tissue is generated from spatial pixels or voxels having positive signal intensities.

Simultaneous non-contrast MR angiography and intraplaque hemorrhage (SNAP) MR imaging

An improved motion-sensitization driven equilibrium (iMSDE) sequence based upon an MLEV-4 sequence is used for black-blood vessel wall imaging. The MSDE pulse pattern that is used us a preparation sequence for other procedures employed to acquire images has been modified to produce the iMSDE sequence by the addition of a second 180 degree refocusing pulse and two motion sensitization gradients. The iMSDE sequence thus includes a group of four radio frequency (RF) pulses, as well as additional magnetic gradient pulses that are not included in the conventional MSDE sequence. Computer simulations indicate that this new pulse sequence is substantially more immune to local B1 inhomogeneity than conventional sequences. In vivo experiments have demonstrated significant signal improvement at high first-order moments (m) conditions compared to the traditional MSDE sequence.

Growing community of inventors

Seattle, WA, United States of America

Jinnan Wang