Tsinghua University

National Health Research Institutes

Jinn-Jer Peir

Fong-In Chou

Chung-Shi Yang

Jen-Kun Chen

Mo-Hsiung Yang

Chih-Hui Liu

Hong-Ming Liu

Mei-Hui Shih

Hsiao-Ping Chung

Sy-Yu Lin

Mei-Ya Wang

The present invention provides a boron drug for boron neutron capture therapy for liver cancer, which is an aqueous solution of boric acid.

Use of boric acid in boron neutron capture therapy for liver cancer

Methods of preparing a composition comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing an aqueous composition comprising gold (Au-197) ions in the absence of a template; and b) exposing the aqueous composition in the absence of the template to neutron irradiation to generate the composition comprising the non-ionic R-GNPs. Alternatively, the method comprises: a) providing an aqueous composition comprising gold (Au-197) nanoparticles (GNPs) in the absence of a template; and b) exposing the aqueous composition comprising the GNPs in the absence of the template to neutron irradiation and thereby generating the composition comprising the non-ionic R-GNPs. Compositions that comprises mesoporous silica nanoparticles (MSNs) and non-ionic R-GNPs encapsulated within pores and/or channels and further anchored to the surfaces of the MSNs, and methods of making the same are also disclosed.

Radioactive gold nanoparticles and methods of making and using them

Growing community of inventors

Hsinchu, Taiwan

Jinn-Jer Peir