Southwest Petroleum University

Sichuan Kelun-biotech Biopharmaceutical Co., Ltd.

Engineering Technology Research Institute, Southwest Oil and Gas Field Company of Petro China

Jinming Liu

Jingyi Wang

Zhi Zhang

Duo Hou

Jian Ding

Jiawei Wang

Pengfei Sang

Yuanjin Zhao

Lichun Wang

Tongtong Xue

Qiang Tian

Hongmei Song

Jiaqiang Cai

Yongyong Wu

Xiankang Zhong

Lin Zhang

Huali Zhang

Yufei Li

Wei Luo

Chuanlei Wang

Wei Yin

Yun Ren

Nan Cai

A compound represented by formula (I) or a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a polymorph, a solvate, an N-oxide, an isotope labeled compound, a metabolite or a prodrug thereof, a pharmaceutical composition and a pill container comprising same, a preparation method therefor, and the use thereof in the preparation of drugs for preventing or treating STING-mediated related diseases.

Benzothiophene compound, preparation method therefor and use thereof

The present invention generally relates to an isoxazole derivative, a preparation therefor, and a use thereof. In particular, the present invention provides a farnesoid X receptor (FXR) agonist compound, and a stereoisomer, a tautomer, a polymorph, a solvate (e.g., a hydrate), a pharmaceutically acceptable salt, an ester, a metabolite, and an N-oxide, and the chemically protected forms and prodrugs thereof. The present invention further provides a preparation method for the compound, an intermediate thereof, and a pharmaceutical composition and kit containing the same and used thereof for treating FXR-mediated diseases or conditions.

Isoxazole derivative, preparation method therefor, and use thereof

A piston pressure device includes a gas concentration-regulating piston pressure device and a high temperature autoclave. In the gas concentration-regulating piston pressure device, the proportion and concentration of corrosive gases can be accurately adjusted, intermediate gases can be stored and filled into the high temperature autoclave according to experimental needs, and an actual corrosion process in oilfield is accurately simulated. Meanwhile, the corrosive gases can be supplemented in real time during the experiment, and dynamic gas distribution in a high-temperature high-pressure corrosion experiment process is realized. The present invention has the advantages as follows: the piston pressure device is resistant to high temperature and high pressure, corrosion-resistant, simple in structure and convenient to operate; the concentration and proportion of the corrosive gases are accurately controlled to be invariable in the high-temperature high-corrosion experiment process; and reliability of high-temperature high-pressure corrosive experimental results is increased.

Intermediate gas concentration-regulating piston pressure device for high-temperature autoclave and gas distribution method

A rotary fatigue tester with complex loads includes a pump, a first motor, a second motor, a circulatory loop, an experimental kettle body, and a holding device. The experimental kettle body is a cylindrical tank, the circulatory loop is located on the experimental kettle body, a pump is located within the circulatory loop and is connected with a corrosive gas pipeline; the holding device is located within the experimental kettle body for fixing a test piece, a force-bearing pole is located at one side of the experimental kettle body for applying a shear force to the test piece, the holding device and the force-bearing pole are connected with the first motor and the second motor respectively. The rotary fatigue tester is able to simultaneously apply the axial alternating load and tangential alternating load to the test piece, for simulating the force of the test piece under complex loads.

Rotary fatigue tester with complex loads

Growing community of inventors

Sichuan, China

Jinming Liu