Agency for Science, Technology and Research

Institute of Molecular Agrobiology

Jinling Xu

Yihu Dong

Lianhui Zhang

Haibao Zhang

Lian-Hui Zhang

Jien Wu

Xifen Zhang

The present invention relates to novel polyamino polyketide antibiotics, methods of their production as well as methods of using these antibiotics, for example, for inhibition or removal of biofilm formation or for treating bacterial infection with these antibiotics.

Polyamino polyketide antibiotics and uses thereof

The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group consisting ofHXHXDH&#x2dc;60aa&#x2dc;H&#x2dc;21aa&#x2dc;DandHXHXDH&#x2dc;72aa&#x2dc;H&#x2dc;21aa&#x2dc;D, and to expression vectors and transformed plant and animal cells comprising the same. The proteins encoded by these nucleic acid molecules provide to a susceptible plant or animal increased resistance to a disease the virulence of which is regulated by autoinducers. Also provided are methods of increasing disease resistance in susceptible plants and animals.

Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals

The present invention relates to isolated nucleic acid molecules encoding a bacterial autoinactivation protein and methods for increasing disease resistance and preventing or reducing bacterial damage in plants and animals. The nucleic acid that encodes the bacterial autoinducer inactivation protein can be introduced into a cell so that the bacterial autoinducer inactivation protein is expressed by the plant or animal. The nucleic acid may confer resistance to disease where the expression of pathogenic genes are regulated by autoinducers.

Nucleic acid molecules encoding bacterial autoinducer inactivation protein as targets for engineering disease resistance

Transgenic plants having resistance against bacterial soft rot diseases, harboring the bacterial autoinducer inactivation gene encoding (AiiA) protein, and methods for protecting plants from bacterial pathogens by transforming the plants with the aiiA gene are disclosed.

Growing community of inventors

Singapore, Singapore

Jinling Xu