Corning Incorporated

Jinlin Peng

Brian L Webb

Anping Liu

Ann MeeJin Ferrie

Ye Fang

Joydeep Lahiri

Po Ki Yuen

Norman Henry Fontaine

Yulong Hong

Guangshan Li

Sadashiva K Pai

Jacques Gollier

Timothy Michael Gross

Garrett Andrew Piech

James Gregory Couillard

John T Keech

Thomas Mark Leslie

Michael Brian Webb

Donnell Thaddeus Walton

David M Root

Lin He

Anthony Glenn Frutos

Keith A Horn

Youchun Shi

Bernice I Feuer

Jeffrey Glenn Lynn

Mircea Despa

Michael Donavon Brady

Ma Sha

James B Stamatoff

Stephen J Carracci

A magnetizable glass ceramic composition including:

Magnetizable glass ceramic composition and methods thereof

The present disclosure relates to buffers containing polyols for use with affinity-binding and/or magnetically susceptible thermoplastic particles and methods of making and use thereof.

PCR reaction cleanup buffers

A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

Variable penetration depth biosensor

Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors

Buffered assay solutions for performing 1) binding or 2) functional assays on GPCR arrays, along with methods for their use are described. The buffered assay solution has an underlying composition having: a buffer reagent with a pH in the range of about 6.5 to about 7.9; an inorganic salt of either a monovalent or divalent species, at a concentration from about 1 mM to about 500 mM; and optionally a combination of: c) a blocker reagent at a concentration of about 0.01 wt. % to about 2 wt. % of the composition, or d) protease-inhibitor at a concentration of about 0.001 mM to about 100 mM. In an embodiment for functional assay uses, the composition is modified to also include a GTP-analogue, a guanosine 5'-diphosphate (GDP) salt, and/or an anti-oxidant reagent.

Assay solution compositions and methods for GPCR arrays

An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.

Spatially scanned optical reader system and method for using same

A biological assay device for use in molecular biology, pharmaceutical research, genomic analysis, combinatorial chemistry, and in the general field of the analysis of molecules that may be deposited on supports of various kinds is provided. Specifically, the present invention includes a fluidic or microfluidic device, which integrates fluidic capability into existing multi-well plates of standard configuration, for performing either single or continuous fluidic manipulations in a high-throughout format. Methods for the use and manufacture of these devices are also provided.

Microcolumn-based, high-throughput microfluidic device

A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.

Microcolumn-platform based array for high-throughput analysis

Methods and compositions useful for capturing proteins or peptides from a sample mixture and analyzing the captured proteins or peptides via high throughput electrospray ionization (ESI) or matrix-assisted laser desorption/ionization mass spectrometry (HT MALDI MS) are provided. The methods and compositions are useful in large scale, simultaneous analyses of proteins and peptides present in a cell(s), tissue(s), or biological fluid(s).

Peptide or protein-capturing surfaces for high throughput MALDI mass spectrometry

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Painted Post, NY, United States of America

Jinlin Peng