Shanghai Mabgeek Biotech. Co., Ltd

Sunshine Guojian Pharmaceutical (shanghai) Co., Ltd.

Sunshine Guojian Pharmaceutical (shanghai) Co., Lt

Jinlin Guo

Chenghai Zhang

Lingqiao Zhu

Wei Dang

Jie Zhao

Honghai Gao

Yujing Yuan

Yan Yang

Le Zhao

Yang Wang

Haomin Huang

Zhenping Zhu

Jianhe Chen

Lin Ma

Yipan Wu

Qiuling Zou

Shun Hu

Disclosed are an antibody that can bind to human MASP-2, a preparation method therefor and an application thereof. The anti-human MASP-2 antibody of the present invention can specifically bind to human MASP-2, has good biological activity of inhibiting the cleavage of C4 and the generation of C3b, and can be applied in the treatment of MASP-2 related diseases, such as IgA nephropathy.

Anti-human MASP-2 antibody, preparation method therefor and application thereof

The present invention discloses an antibody capable of binding to human interleukin 4 receptor alpha (hIL-4R alpha) and a preparation method and application thereof. The anti-hIL-4R alpha antibody can specifically bind to hIL-4R alpha, has good effects for inhibiting IL-4 and IL-13-induced cell line proliferation and the like, and can be applied to treatment of IL-4R alpha related diseases, such as immune-mediated inflammatory diseases.

Anti-human interleukin-4 receptor alpha antibody and preparation method and application thereof

An anti-human PD-1 monoclonal antibody, and a preparation method therefor and an application thereof. The anti-human PD-1 monoclonal antibody has good bioactivity, can effectively bind with an extracellular region of a human PD-1 protein receptor, and can effectively seal PD-1 protein at protein level and cellular level and block the binding of the PD-1 protein with a ligand PD-L1, thereby effectively enhancing immunity. The monoclonal antibody can be applied independently or jointly with other antitumor drugs to tumor immunotherapy and the diagnosis and screening of patients with PD-L1 positive tumors; and the monoclonal antibody has a promising prospect in the preparation of drugs for treating tumors, resisting autoimmune diseases and the like.

Anti-PD-1 monoclonal antibody, and preparation method therefor and application thereof

An anti-human IL-17A monoclonal antibody, the preparation method, and the use thereof are provided. The anti-human IL-17A monoclonal antibody can specifically bind to human IL-17A and has a good effect for inhibiting the secretion of inflammatory cytokines, such as IL-6 and the like by means of various cell lines induced by IL-17A, and can be used for preparing drugs for treating diseases involving immune-medicated inflammatory responses.

Anti-human interleukin-17A monoclonal antibody

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Shanghai, China

Jinlin Guo