Shanghai Desano Chemical Pharmaceutical Co., Ltd

Shanghai Cdymax Pharmaceuticals Co., Ltd.

Shanghai Desano Pharmaceutical Holding Co., Ltd.

Shanghai Desano Pharmaceuticals Science & Technology Development Co., Ltd.

Shanghai Desano Pharmaceutical Science & Technology Development Co., Ltd.

Jinliang Li

Nan Zhao

Feng Lv

Zuwang Wu

The present invention provides a process for preparing pemetrexed disodium and its intermediate, 4-(4-carbomethoxyphenyl)butanal. The process for preparing the intermediate comprises the following steps: condensing methyl 4-bromobenzoate with 3-buten-1-ol; extracting with an organic solvent during the work-up; adding silica gel to decolorize; and evaporating the organic solvent to give 4-(4-carbomethoxyphenyl)butanal. The product obtained by the present process, with a yield of higher than 80%, and a purity measured by GC of higher than 95%, may be directly used in the next bromination reaction for synthesizing pemetrexed disodium without purification. The present process is suitable for industrial production, as the operation is simple and the reagents used are cheap and readily available.

Process for preparing pemetrexed disodium and its intermediate, 4-(4-carbomethoxyphenyl) butanal

The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.

Process for stereoselective synthesis of lamivudine

A method to prepare Docetaxel trihydrate using the mixture of acetone and water, which provides the product with good stability, less experiment time, less exposal to light, and avoids purity decreasing. The process is simple and easy to operate.

Process for the preparation of docetaxel trihydrate

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Shanghai, China

Jinliang Li