Sunshine Lake Pharma Co., Ltd.

Jinlei Liu

Yingjun Zhang

Jiancun Zhang

Bing Liu

Lu Zhang

Jiquan Zhang

Changchung Cheng

Weihong Zhang

Provided herein are aminoquinazoline compounds, salts and uses thereof. The compounds have Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Also provided herein are pharmaceutical compositions containing the compounds disclosed herein, and uses of the compounds or the compositions for preventing, managing, treating or lessening the severity of a proliferative disorder in a patient and for modulating the protein tyrosine kinase activity. 

Aminoquinazoline derivatives and their salts and methods of use thereof

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Aminoquinazoline derivatives and their salts and methods of use

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Dongguan, China

Jinlei Liu