Seikagaku Corporation

Seikagaku Kogyo Kabushiki Kaisha

Seikagaku Kogyo Kabushiki Kaisha (seikagaku Corporation)

Jinichi Inokuchi

Masayuki Jinbo

Haruki Yamada

Hidekazu Oyamada

Seigou Usuki

Takayuki Nagai

Seiichiro Ogawa

Yoichiro Kuroda

Kazuyo Muramoto

Amino alcohol derivative and method for preparing the same

Amino alcohol derivatives with a primary amino group or a substituted amino group influence the synthesis of glycolipids and have antiviral, antitumor, metastasis inhibiting and neural cell growth enhancing functions. The amino alcohol derivatives are useful in preparing 2-acylamino alcohol derivatives.

The present invention provides a compound which is a glycolipid analog having a novel structure represented by the formula (1): ##STR1## wherein Z represents an imino group, an oxygen atom or a sulfur atom; m is an integer of from 3 to 12; and n is an integer of from 4 to 22; and shows a potent activity of inhibiting glycosidase and has potential physiological activities, for example, antiviral activity. The invention also provides a glycosidase inhibitor which comprises said glycolipid analog as an active ingredient.

Glycolipid analogs

Disclosed is an agent for curing neuronal diseases caused by disorders of peripheral nervous system or central nervous system, which comprises a 2-acylaminopropanol compound of the formula: ##STR1## wherein R.sup.1 represents a phenyl group or cyclohexyl group each of which may be substituted by 1 to 3 same or different substituents selected from the group consisting of alkyl, alkoxy, hydroxy and nitro, or represents an alkyl group, and n represents an integer of 0 to 16, or a pharmaceutically acceptable salt thereof as an effective ingredient.

Method for treating neuronal diseases via administration of

2-acylaminopropanol compound and medical composition

Agent for treating neuronal diseases

Growing community of inventors

Tokyo, Japan

Jinichi Inokuchi