Dana-farber-cancer Institute Inc.

Tsinghua University

Beijing Zhendong Guangming Pharmaceutical Research Institute Co., Ltd.

Jinhua Wang

Nathanael Schiander Gray

Xianming Deng

David Waller

Hwan Guen Choi

Yue Li

Bin Wu

Zuoyi Zhang

Bing Liu

Haitao Wang

Fu Li

Yujie Dong

Dennis Dobrovolsky

Hongyu Wang

Siju Zhang

Jiong Guo

Wenjie Qin

Xiaoning Yang

Juanjuan Liang

Hongjiang Hao

Multiple groups of nuclear fuel storage containers can be put into the nuclear fuel transport container provided by the present application as a whole to realize the overall transportation of the multiple groups of storage containers; the transport container has a cubic structure in appearance, which can fully utilize the transportation space and improve the transportation efficiency; an outer side of the transport container is provided with an anti-penetration structure, which can effectively alleviate the collision and penetration damage caused by transportation and hoisting accident, and ensure that the nuclear fuel element can be safely enclosed after the accident; heat insulation material is provided between inner and outer steel plates of the transport container, which can effectively protect the internal storage container and the loaded nuclear fuel element under fire condition, and the heat insulation material also has a function of drop buffer.

Method and equipment for transporting nuclear fuel of nuclear power plant

The present application provides bifunctional compounds of Formula X or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for Bruton's tyrosine kinase (BTK). The present application also relates to methods for the targeted degradation of BTK through the use of bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to BTK which can be utilized in the treatment of disorders modulated by BTK.

Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use

The invention relates to the field of traditional Chinese medicine, in particular to provides traditional Chinese medicine compositions for the treatment of psoriasis, their preparations and their preparation methods. The Chinese medicine compositions of the invention are consisted of 20-80 parts of20-80 parts of Radix10-50 parts of Herba10-40 parts of Chineseand 5-30 parts ofby weight. The invention also includes the preparation methods of the traditional Chinese medicine compositions and the preparations containing the traditional Chinese medicine compositions and method for preparing the same. The pharmacological experiments and clinical experiments proved that the traditional Chinese medicine compositions of the invention have remarkable curative effects on psoriasis vulgaris, high cure rate, no toxic and side effects of hormones, and is suitable for the characteristics of psoriasis having long-term use due to the long-course of the diseases.

Traditional Chinese medicine composition for treating psoriasis and method for preparing the same

A nuclear power plant spent fuel negative pressure unloading system comprises a fuel element transport pipe and a gas transport pipe. The fuel element transport pipe comprises a fuel element output pipe, a fuel element lifting pipe, and a fuel element unloading pipe connected in series. The fuel element unloading pipe is arranged obliquely downward in the direction of fuel element movement. The distal end of the fuel element unloading pipe is connected sequentially to fuel loading apparatus and a transfer apparatus. Two nozzles of the gas transport pipe are connected to set positions on the fuel element output pipe and the fuel element unloading pipe respectively. A gas driving mechanism is connected to the gas transport pipe. An inlet of the gas driving mechanism is arranged at one end in proximity to the fuel element unloading pipe.

Nuclear power plant spent fuel negative pressure unloading system

The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1, 2, 3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.

Pyrimido-diazepinone compounds and methods of treating disorders

A residual heat removal ventilation system for spent fuel dry storage facility of nuclear power plant includes a natural ventilation apparatus and a forced ventilation apparatus, comprising a cold air intake chamber, a hot air removal chamber, a pipeline, a ventilation heat shield cylinder, a heat removal fan, and an air cooling equipment having certain connecting relationships and being correspondingly arranged in a storeroom, an operating room and a ventilation equipment room. The system doesn't require storing spent fuel in a pool storage manner. The safety of the spent fuel doesn't rely on power equipment, thus not only reducing routine maintenance, saving energy, but also has inherent safety. Furthermore, the system can be used to cool spent fuel storage canisters within spent fuel storage facility of pebble bed high temperature gas-cooled reactor nuclear power plant, and discharge residual heat of spent fuel storage canisters to the external environment.

Residual heat removal ventilation system for spent fuel dry storage facility of nuclear power plant

Growing community of inventors

Beijing, China

Jinhua Wang