Pharmagenesis, Inc.

Ecopharm Corporation

Phytohealth Corporation

Jinhua An

John H Musser

John M Fidler

Edwin S Lennox

Rensheng Xu

Karen S Leu

The teachings provided herein generally relate to the preparation and uses of compositions comprising extracts of. The extracts are prepared fromand can comprise, for example, an acid-modified arabinogalactan protein composition having an arabinose:galactose ratio ranging from about 3.5:1 to about 5.0:1, from about 5% to about 10% rhamnose, from about 15% to about 20% galactose, and from about 10% to about 15% glucose. The compositions can be used in the treatment of idiopathic thrombocytopenic purpura and the formulation of medicaments for such treatments.

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Methods for extraction, isolation, and purification of therapeutically useful compounds fromare described. Extraction steps employing aqueous base and a hydrocarbon solvent, respectively, are found to increase the efficiency of the process and reduce the amount of material that must be removed by chromatography.

An acid-modified arabinogalactan protein composition, having an arabinose-galactaose ratio of less than 3.5:1, comprising 5&#x2013;10% Rha, 20&#x2013;35% Gal, and less than 5% Glc, prepared from, is useful for treating a number of conditions. For example, an acid-modified arabinogalactan protein composition having features of the invention is useful for stimulating hematopolesis, inducing the proliferation of megakaryocytes, inducing the maturation of megakaryocytes, and stimulating the production of IL-1&#x3b2;, IL-6, TNF-&#x3b1;, IFN-&#x3b3;, GM-CSF, G-CSF, and neutrophils, and stimulating the action of neutrophils; stimulating the immune and/or hematopoietic system of a mammal suffering from neutropenia, anemia, thrombocytopenia, exposure to cytotoxic agents, exposure to radiation, cachexia, emesis, and drug withdrawal symptoms; and is effective to restore the immune response to infection, in immunosuppressive conditions, and to protect hepatic cells in hepatitis B.

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Santa Clara, CA, United States of America

Jinhua An