Dalian University of Technology

Dalian Chromas Bioscience Co., Ltd.

Dalian Firstar Information Materials Co., Ltd.

Dalian Chromas Biosctence Co., Ltd

Jingyun Wang

Xiaojun Peng

Jiangli Fan

Shiguo Sun

Jianjun Du

Mingle Li

Qichao Yao

Hua Zhang

Fengling Song

Jianzhou Zhang

Yanxia He

Zhigang Yang

Si Zhang

Haidong Li

Yana Bian

Honglin Li

Hao Zhu

Saran Long

Disclosed are an oxazine compound and an application thereof. The oxazine compound has a structure of a general formula F. The oxazine compound described in the disclosure is a photo/acoustic dynamic active organic molecule with near-infrared absorption-emission function as well as photosensitivity and acoustic sensitivity. Maximum absorption and emission wavelengths of the compound are both greater than 660 nanometers, and a triplet-state conversion rate of the compound is high; and under illumination or ultrasound, the compound can produce reactive oxygen species with high efficiency, which has a good killing effect on cancer cells and cancer tissues, and almost has no toxic or side effects on normal tissues while achieving photo/acoustic dynamic therapy on tumors.

Oxazine compound and application thereof

A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, Rand Rare independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; Ris selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and Lis a linker selected from &#x2014;(CH)&#x2014; or &#x2014;(CHCHO)&#x2014;. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy. 

Photosensitizer and derivatives and application thereof

The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc. 

Class of cyano-substituted asymmetric cyanine dyes, synthesizing method and application thereof

The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as HO, O, TBHP, HO., TBO.,Oand NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells. 

Difluoroboron dipyrromethene fluorescent probe, production method and application thereof

The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X, X, Xand X; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample. 

Naphthalene-based two-photon fluorescent probes, preparation method and use thereof

The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pdin near-neutral pH range. In detection of Pdin 0-10 ppb level, fluorescence is evidently enhanced, and Pdin the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pdconcentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.

Fluorescent probe compounds, preparation method and application thereof

A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCRR; Rand Rare independently selected from the group consisting of (CH)Rand et al.; Rand Rare independently selected from the group consisting of CN, COOH and COOR; R, Rand Rare independently selected from the group consisting of H, SORand COOR; Ris H or Calkyl; Ris H or CH; Ris N(RRRR); Ris Calkyl; R, R, R, Rand Rare independently selected from the group consisting of H, Calkyl, (CH)ORand (CHRCHO)R; Yis halogen anion or OTs; and n, m and p are integers of 0-18. The dye can be utilized to sensitively detect viscosity of micro-environment such as tissues and cells. 

Pentamethine cyanine fluorescent dyes, preparation methods and uses thereof

The disclosure provides fluorescence probe compounds of formula I, their preparation methods and applications. These compounds are useful in detecting mercury ions.

Growing community of inventors

Liaoning, China

Jingyun Wang