Metabolex, Inc.

Cymabay Therapeutics, Inc.

Jingyuan Ma

Xin Chen

Jiangao Song

Imad Nashashibi

Zuchun Zhao

Yan Zhu

Peng Cheng

Christopher J Rabbat

Alison Murphy

Jeffrey D Johnson

Aaron Robert Novack

Maria E Wilson

L Edward Clemens

Phuongly Pham

Dong Fang Shi

Dong-Fang Shi

David W G Wone

Vera Rakhmanova

Francine M Gregoire

Christoper J Rabbat

Charles A McWherter

Xueyan Wang

Brian Edward Lavan

Aaron Novack

Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.

Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders

The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.

Bicyclic agonists of GPR131 and uses thereof

Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.

N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders

Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.

Agonists of GPR131 and uses thereof

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

GPR120 receptor agonists and uses thereof

The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders. 

2,4-disubsituted thiazoles and pharmaceutical compositions thereof

The present invention provides a compounds the formula (IV): and methods for producing an &#x3b1;-(phenoxy)phenylacetic acid compound of the formula: wherein Ris a member selected from the group consisting of: each Ris a member independently selected from the group consisting of (C-C)alkyl, halo, (C-C)haloalkyl, amino, (C-C)aminoalkyl, amido, (C-C)amidoalkyl, (C-C)sulfonylalkyl, (C-C)sulfamylalkyl, (C-C)alkoxy, (C-C)heteroalkyl, carboxy and nitro; the subscript n is 1 when Rhas the formula (a) or (b) and 2 when Rhas the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R; and compounds.

Process for the stereoselective preparation of (&#x2212;)-halofenate and derivatives thereof

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Sunnyvale, CA, United States of America

Jingyuan Ma