The Johns Hopkins University

Jingxin Wang

Jun O Liu

Zufeng Guo

Manisha Das

Shridhar Bhat

Wei Li

Sam Hong

Zhaoli Sun

Wukun Liu

Hanjing Peng

Jun Liu

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Hybrid cyclic libraries and screens thereof

Compounds with the following structures and their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.

Rapaglutins, novel inhibitors of GLUT and use thereof

A compound of Formula I, and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof

A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions. 

A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided. 

Growing community of inventors

Baltimore, MD, United States of America

Jingxin Wang