Washington University

University of Nebraska

Marshall University Research Corporation

Jingwei Xie

Younan Xia

Matthew MacEwan

Zack Ray

Shixuan Chen

Mark Andrew Carlson

Matthew R Macewan

Stavros Thomopoulos

Shelly E Sakiyama-Elbert

Matthew Silva

Richard Gelberman

Andrea Schwartz

Jiang Jiang

Sunil Kumar Boda

Bernard Timothy Baxter

A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

Biomedical patches with aligned fibers

Nanofiber structures are provided as well as methods of use thereof and methods of making.

Nanofiber structures and methods of manufacture and use thereof

Nanofiber segments comprising polymeric electrospun nanofibers are provided as well as methods of use thereof and methods of making.

Nanofiber segments and methods of use thereof

A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

Coated and expanded, nanofiber structures are provided and methods of use thereof.

Nanofiber structures and methods of use thereof

Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making.

Three dimensional nanofiber structures are provided and methods of production thereof.

Microfiber structures and methods of synthesis and use thereof

Expanded, nanofiber structures comprising electrospun nanofibers, a plurality of holes, and, optionally, cells are provided. Methods of making the nanofiber structures as well as methods of use thereof, particularly for wound healing, are also provided.

Growing community of inventors

St. Louis, MO, United States of America

Jingwei Xie