Sph No. 1 Biochemical & Pharmaceutical Co., Ltd.

Shanghai Ziyuan Pharmaceutical Co., Ltd.

Jinguo Ding

Zhenhui Huang

Hao Liu

Zhigang Zhang

Liuqing Yang

Ning Sun

Wenyan Luo

Jianli Huo

Xiaofen Liu

Xinlei Zhu

Xingchen Bian

Hanzhi Zhang

A polymyxin B component or salts thereof, and a preparation and application thereof. The polymyxin B component includes six &#x3b1;,&#x3b3;-diaminobutyric acids respectively at positions 1, 3-5 and 8-9, two threonine residues at positions 2 and 10, a phenylalanine residue at position 6 and a leucine residue at position 7 linked in sequence. The threonine residue at position 10 is linked to the &#x3b1;,&#x3b3;-diaminobutyric acid at position 4 by an amido bond, and the &#x3b1;,&#x3b3;-diaminobutyric acid at position 1 is linked to 6-methyloctyl-2-enoyl.

Polymyxin B component or salt thereof, and preparation and application thereof

Disclosed are a crystallization water-free calcium dibutyryladenosine cyclophosphate crystal form, and a preparation method and a use thereof. In an X-ray powder diffraction pattern using Cu-K&#x3b1; as a source of radiation, the crystallization water-free calcium dibutyryladenosine cyclophosphate crystal form has characteristic peaks at positions where diffraction angles 2&#x3b8; are equal to 12.3&#xb0;&#xb1;0.2&#xb0;, 17.6&#xb0;&#xb1;0.2&#xb0;, 21.4&#xb0;&#xb1;0.2&#xb0;, 24.7&#xb0;&#xb1;0.2&#xb0;, 25.3&#xb0;&#xb1;0.2&#xb0; and 27.8&#xb0;&#xb1;0.2&#xb0;. The crystallization water-free calcium dibutyryladenosine cyclophosphate crystal form of the present invention has a high purity, and good stability; the preparation method is simple and convenient, has good reproducibility, and is easy to industrially popularize and apply.

Crystal-water-free calcium dibutyryladenosine cyclophosphate crystal form and preparation method and application thereof

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Jinguo Ding