Shanghai Clear Fluid Biomedical Science Co., Ltd.

Shanghai Puyou Biomedical Co., Ltd.

Jingpeng Fu

Yinghao Zhang

Jia Wan

Yao Wang

Guirui Yan

Described herein is a method for preventing or treating atherosclerosis or atherosclerosis-related diseases in an individual in need thereof, the method comprising: administering to the individual a therapeutically effective amount of sDSS1 protein or a fragment or variant thereof, a nucleic acid encoding the sDSS1 protein or a fragment or variant thereof or a vector containing the nucleic acid, transplanting into the individual with a cell expressing the sDSS1 protein or a fragment or variant thereof, or tissues or organs containing the sDSS1 protein or a fragment or variant thereof or the nucleic acid, and/or infusing into the individual serum or interstitial fluid containing the sDSS1 protein or a fragment or variant thereof or the nucleic acid.

Methods and compositions for preventing and treating atherosclerosis and related diseases

The disclosure of the present application relates to a secretory deleted split hand/split foot 1 (sDSS1) protein, the amino acid sequence thereof, the nucleic acid sequence thereof, and the applications of the same. The sDSS1 protein is a secretory protein from higher primate, and can be detected in human serum and cerebral spinal fluid (CSF). The sDSS1 protein can form conjugate with oxidized protein under nonenzymatic condition or with amyloid-beta (A&#x3b2;) polypeptide to reduce formation of A&#x3b2; oligomer. The addition of sDSS1 protein to culture medium can shield the cytotoxicity induced by oxidized protein, A&#x3b2; oligomer, amylin oligomer and glycosylated protein, so as to protect the cells against these toxoproteins. The sDSS1 protein can prolong survival time of senescence-accelerated mice significantly. The protein can be used to prevent and treat the diseases induced by oxidized protein, glycated protein, A&#x3b2; protein accumulation, amylin protein accumulation or excessive formation or accumulation of other pathogenic proteins with similar features, and has important potential in biological medicine.

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Shanghai, China

Jingpeng Fu