Tianjin University

Nantong Licheng Biological Engineering Co. Ltd

Hainan Lingkang Pharmaceutical Co., Ltd

Shenzhen Salubris Pharmaceuticals Co. Ltd.

Shenzhen Gosun Pharmaceutical Co., Ltd.

Shenzhen China Resources Gosun Pharmaceutical Co., Ltd.

Jingkang Wang

Baohong Hou

Junbo Gong

Qiuxiang Yin

Qinqing Gu

Shichao Du

Kaifei Zhao

Linggang Tao

Ying Bao

Chuang Xie

Duanming Tan

Jun Lv

Hongxun Hao

Jiangbo Li

Yi Sun

Qi Wang

Xiaohua Wu

Fang He

Yongli Wang

Feng Jin

Shiping Tang

Xiaopeng Song

Liting Liao

Ziyuan Di

Xin Pan

Yuxin Qian

Meijing Zhang

Haiyan Xi

Zhongshi Liu

Jiehua Wu

Zhan'ao Yang

A method for preparing a new crystalline form of &#x3b3;-aminobutyric acid, including the steps of: S1: preparing a &#x3b3;-aminobutyric acid solution at an initial concentration of 0.5-1.0 g/mL by adding crude &#x3b3;-aminobutyric acid to water; adding an additive to the &#x3b3;-aminobutyric acid solution, raising the temperature to 50-80&#xb0; C., stirring to produce a clear solution; and S2: obtaining a suspension by evaporating water from the product of S1 under reduced pressure and at 50-80&#xb0; C.; obtaining a wet product by filtering the suspension; drying the wet product to obtain the new crystalline form of &#x3b3;-aminobutyric acid. The preparation method of the new crystalline form of &#x3b3;-aminobutyric acid is simple, easy to operate, low in energy consumption, economical and environmentally friendly. It is suitable for large-scale industrial production.

Crystalline form of gamma-aminobutyric acid and preparation method thereof

The present invention discloses a &#x3b3;-aminobutyric acid hemihydrate crystal, its molecular formula is CHNO.0.5HO. It also discloses a method of preparing a &#x3b3;-aminobutyric acid hemihydrate crystal, including first adding crude &#x3b3;-aminobutyric acid to water to prepare a &#x3b3;-aminobutyric acid suspension at an initial concentration of 1.2-2.0 g/mL; then stirring the suspension at a constant temperature of 5-10&#xb0; C. for 6-12 hours, followed by filtering and drying to obtain the &#x3b3;-aminobutyric acid hemihydrate crystal. The &#x3b3;-aminobutyric acid hemihydrate crystal is stable, does not easily absorb moisture and agglomerate, and is convenient for further processing and use. The crystal has a large main particle size, uniform particle size distribution, high bulk density, good flowability, and a purity of &#x2265;99%. The preparation method of the crystal according to the present invention is simple, easy to operate, highly efficient and low in energy consumption, and is suitable for large-scale industrial production.

Gamma-aminobutyric acid hemihydrate crystal and preparation method thereof

A novel crystalline form is defined by diffraction angle 2&#x3b8;&#xb0; of X-ray powder diffraction pattern and characteristic peak of differential scanning calorimetry (DSC). The novel crystalline form of Cefamandole Nafate is prepared as follows: adding Cefamandole Nafate in solid state to an organic solvent to form a suspension with a concentration of 0.04&#x2dc;0.3 g/ml, stirring the suspension at 40&#x2dc;50&#xb0; C. for a period of time, and then cooling to 5&#x2dc;15&#xb0; C. at certain cooling rate, continuing to stir for a period of time, then suction filtrating the obtained suspension, the resulting filer cake is Cefamandole Nafate as wet product, which is dried to constant weight to provide the novel crystalline form of Cefamandole Nafate as final product.

Crystalline form of cefamandole nafate compound, preparation and preparing method thereof

This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the concentration, addition way and addition speed of sulfuric acid used to salify to shorten the process time, thus separating out Clopidogrel Hydrogen Sulfate from solution system stably with spherality. And the Clopidogrel Hydrogen Sulfate obtained complies with the requirements of the follow-up process on residual solvent, bulk density and mobility.

Method for preparing spherical Clopidogrel Hydrogen Sulfate polymorph I

The present invention relates to cefazolin sodium pentahydrate crystal and a method for assembly and preparation of the crystal molecule. The cefazolin sodium pentahydrate crystal molecule contains five water molecules, orthorhombic system, space group of C222(1), in which sodium ion is bonded to the cefazolin molecule with a coordinate bond. The method for assembly and preparation of cefazolin sodium pentahydrate crystal molecule are: adding a solvent to a reactor equipped with a jacket, adding cefazolin acid and a sodium salt, heating until the reaction solution is clear, stirring continuously, adjusting pH, upon the completion of the reaction, transferring the liquid into a jacketed crystallizer, adding crystal seeds or nucleating spontaneously, controlling cooling, slowly adding a antisolvent. The particle size of cefazolin sodium pentahydrate crystal according to the present invention is adjustable, and the distribution of particle size is concentrated, the product has good flowability, smooth surface, high crystallinity, good stability, and rapid dissolving rate.

Cefazolin sodium pentahydrate crystal and its molecular assembly preparation method

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Tianjin, China

Jingkang Wang