University of Illinois

Osong Medical Innovation Foundation, Korea University Research and Business Foundation

Zimitech, Inc.

Jingjing Liu

Yong-Su Jin

Kyoung Heon Kim

Sora Yu

Eun Ju Yun

Kulika Chomvong

Suryang Kwak

Jaewon Lee

Jamie H D Cate

Guochang Zhang

Compositions and methods are provided for producing 2'fucosyliaciose and L-fucose from recombinant microorganisms.

Engineered microorganisms for production of 2'fucosyllactose and l-fucose

The present disclosure provides genetically engineered microorganisms for tagatose production comprising one or more heterologous polynucleotides encoding polypeptides selected from cellodextrin transporter (Cdt-1), intracellular &#x3b2;-glucosidase (Gh1-1), xylose reductase (XR), galactitol 2-dehydrogenase (Gdh) and an AraA polypeptide, wherein any biological activity of endogenous Gal1 is attenuated or eliminated. Also provided are genetically engineered microorganism for psicose production comprising one or more heterologous polynucleotides encoding polypeptides selected from alpha-glucoside permease (Agt1) and psicose epimerase (Dpe), wherein any biological activity of endogenous sucrose invertase (Suc2), hexose kinase 1 (Hxk1), hexose kinase 2 (Hxk2), or combinations thereof are attenuated or eliminated. Methods of converting lactose to tagatose and sucrose to psicose is also provided.

Recombinant microorganisms for conversion of oligosaccharides into functional sweeteners

Growing community of inventors

Urbana, IL, United States of America

Jingjing Liu