Agios Pharmaceuticals, Inc.

Jingjing Ji

Zhihua Sui

Tao Liu

Giovanni Cianchetta

Dawei Cui

Anil Kumar Padyana

Zhenwei Cai

Charles Kung

Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R, R, R, R, R, R, and Q are as defined herein.

Pyruvate kinase activators for use in treating blood disorders

Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): wherein R, R, L, and Lare as defined herein.

Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R, R, L, and Lare as defined herein.

Pyruvate kinase modulators and use thereof

Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R, R, R, R, R, R, and Q are as defined herein. 

Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R, R, L, and Lare as defined herein. 

Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): wherein R, R, L, and Lare as defined herein. 

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Shanghai, China

Jingjing Ji