Elanco US Inc.

Eli Lilly and Company

University of Notre Dame Du Lac

Jingdan Hu

Timothy Andrew Woods

John M Schaus

Marvin J Miller

David Edward Tupper

Joseph H Krushinski, Jr

David Scott Coffey

Stacy Jo Keding

Guanmin Wu

Xin Zhang

Ping Huang

Jing Chen

Jean Marie Defauw

John Mehnert Schaus

Joseph Herman Junior Krushinski

The present disclosure provides processes for making enantiomerically pure isoxazoline compounds of formula (1), The present disclosure also provides processes for making enantiomerically pure isoxazoline compounds of formula (1) characterized by improving the enantiomeric purity of 3-methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]thiophene-2-carboxylic acid by crystallization.

Process for making an isoxazoline compound and intermediate thereof

The present disclosure provides crystalline forms of 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(cyclopropylsulfonyl)azetidin-3-yl)acetonitrile, pharmaceutical compositions comprising the crystalline forms, methods of using the crystalline forms, and processes for making the crystalline forms.

Crystalline forms of 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(cyclopropylsulfonyl)azetidin-3-yl)acetonitrile

Process for making crystalline 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(cyclopropylsulfonyl)azetidin-3-yl)acetonitrile

CB-1 receptor inverse agonist compounds of Formula and pharmaceutical compositions for the treatment of obesity or cognitive impairment associated with schizophrenia.

1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands

Compounds and pharmaceutical compositions comprising compounds of the Formula as CBreceptor inverse agonists useful for reducing body weight in mammals, treating cognitive impairment associated with schizophrenia, and mitigating treatment emergent weight gain observed during treatment with antipsychotics.

1, 5-diphenyl-3-benzylamino-1, 5-dihydropyrrolidin-2-one as CB1 receptor modulators

Heterocyclic antituberculosis agents

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Carmel, IN, United States of America

Jingdan Hu