Massachusetts Institute of Technology

Novartis Ag

Jing Zhou

Chiping Chen

Feng Cong

Asher Schachter

Nathalie George

Dong Liu

Ronak J Bhatt

William Dietrich

Aditi Soni

Alexey L Radovinsky

Thomas M Bemis

The present invention relates to antibodies and antigen-binding fragments thereof to human BMP6 and compositions and methods of use thereof.

Compositions and methods for antibodies targeting BMP6

The present invention relates methods of treatment using BMP6 antagonists.

Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6)

A permanent magnet focusing system includes an electron gun that provides an electron ribbon beam having an elliptical shape. A plurality of permanent magnets provide transport for the electron ribbon beam. The permanent magnets produce a non-axisymmetric periodic permanent magnet (PPM) focusing field to allow the electron ribbon beam to be transported in the permanent magnet focusing system.

Non-axisymmetric periodic permanent magnet focusing system

A high-brightness, space-charge-dominated circular charged-particle beam system includes a flat circular emitter that emits charge particles to form a space-charge-dominated circular charged-particle beam. The space-charge-dominated circular charged-particle beam is emitted from the flat circular emitter with a uniform density and having a current emission being space-charge-limited, obeying the Child-Langmuir law. A diode includes at least one electrode at the flat circular emitter and at least one additional electrode that accelerates the charged particles. A beam tunnel is coupled electrically to at least one of the additional electrodes. An applied axisymmetric magnetic field focuses the space-charge-dominated circular charged-particle beam. A depressed collector collects the space-charge-dominated circular charged-particle beam.

Generation, acceleration, focusing and collection of a high-brightness, space-charge-dominated circular charged-particle beam

The charged-particle beam system includes a non-axisymmetric diode forms a non-axisymmetric beam having an elliptic cross-section. A focusing element utilizes a magnetic field for focusing and transporting the non-axisymmetric beam, wherein the non-axisymmetric beam is approximately matched with the channel of the focusing element.

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Cambridge, MA, United States of America

Jing Zhou