Huazhong University of Science and Technology

Jing Zhong

Wenzhong Liu

Pu Zhang

Le He

Ling Jiang

Yin Yan Li

Ming Yang

Ming Zhou

Wenping Mao

Zhongzhou Du

Di Xie

Shiqiang Pi

The present disclosure relates to methods and systems for magnetic nanoparticle temperature imaging. Particularly, the present methods involve applying different combinations of magnetic fields to magnetic nanoparticles placed in a one-dimensional space, collecting AC magnetization signals of the magnetic nanoparticles, and analyzing the collected signals to obtain in vivo temperature information of the one-dimensional space. Different exciting magnetic fields are applied to the magnetic nanoparticles, so that one-dimensional temperature imaging is transformed into single-point temperature measurement of each minizone, and one-dimensional temperature imaging can be precisely and quickly achieved without knowing the concentration distribution of the magnetic nanoparticles.

Magnetic nanoparticle temperature imaging method and magnetic nanoparticle temperature imaging system

Provided is a magnetic nano temperature measurement method under a triangle wave excitation magnetic field relating to a technical field of nano measurement. The method further comprises steps of: (1) positioning a magnetic nano sample at a measured object; (2) applying a triangle wave excitation magnetic field on area of the magnetic nano sample; (3) detecting a triangle wave excitation magnetic field-time curve and a magnetization-time curve of the magnetic nano sample; (4) obtaining a magnetizing curve of the magnetic nano sample, namely excitation magnetic field-magnetization curve, by the triangle wave excitation magnetic field curve and the magnetization curve, and sampling the magnetizing curve to obtain magnetization Mof the magnetic nano sample under excitation magnetic field H; and (5) determining temperature of the measured object by curve fitting with excitation magnetic field Has input, magnetization Mas output, and a relationship between the excitation magnetic field and the magnetization as objective function. The invention obtains a magnetizing curve rapidly using a triangle wave excitation magnetic field, and realizes real-time and precise temperature measurement based on magnetic nanoparticles by inversion algorithms according to the magnetizing curve based on a temperature measurement model of magnetic nanoparticles under a DC magnetic field.

Magnetic nano temperature measurement method using triangle wave excitation magnetic field

The invention discloses a method for in-vivo temperature measurement based on AC magnetization of magnetic nanoparticles, and relates to a nano test technology field. The invention positions magnetic nano agent at an area of a measured object, applies an AC excitation magnetic field to the area of the magnetic nano agent, collects an AC magnetization signal of the magnetic nano agent under the AC excitation magnetic field, detects amplitudes of odd harmonics of the AC magnetization signal, and finally calculates in-vivo temperature according to a relationship between the odd harmonics and the in-vivo temperature. The invention predetermines the relationship between the odd harmonics and the in-vivo temperature via the discrete Langevin's function and the Fourier transformation, solves the in-vivo temperature according to the relationship without considering concentration of the magnetic nanoparticles, and effective moment as temperature varies, and thus accurately detecting the in-vivo temperature.

Method and system for in-vivo temperature measurement based on AC magnetization of magnetic nanoparticle

The invention discloses a paramagnetism-based remote temperature measurement method for magnetic nanoparticles, and the method comprises: applying multiple times of excited magnetic fields on the area of a magnetic nano sample, constructing an equation group between the different excited magnetic fields and corresponding magnetic susceptibilities according to the Langevin's paramagnetic theorem, and obtaining the information of temperature and sample concentration via the equation group. The invention is capable of more precisely and more quickly detecting the temperature of an object, and especially applicable for the detection of thermal motion at bio-molecular level. Experiments indicate the measurement error is less than 0.56K.

Paramagnetism-based remote temperature measurement method for magnetic nanoparticle

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Wuhan, China

Jing Zhong