Entasis Therapeutics, Inc.

Jing Zhang

Ruben Alberto Tommasi

Thomas Francois Durand-Reville

Xiaoyun Wu

Janelle Comita-Prevoir

Jan Romero

Jeroen Cunera Verheijen

Frank Wu

Satenig Guler

Mark Sylvester

Camilo Velez-Vega

Lise Gauthier

John O'Donnell

Gregory S Basarab

Bill Moss

Provided herein are antibacterial compounds represented by Formula I, or a pharmaceutically acceptable salt thereof, wherein X, Y, R, R, and Rare as defined herein. Also provided are pharmaceutical compositions comprising the compounds of Formula I. 

Compounds and methods for treating bacterial infections

The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts are useful in combination with beta-lactam antibiotics, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of R, R, R, R, Rand Rare described herein. 

Beta-lactamase inhibitor compounds

Growing community of inventors

Sudbury, MA, United States of America

Jing Zhang