Other

Crystal Pharmaceutical (Suzhou) Co., Ltd.

Jiangsu University

Medshine Discovery Inc.

Jiangsu University of Science and Technology

Crown Bioscience, Inc. (Taicang)

Changzhou Ruihua Chemical Engineering Technology Co., Ltd.

Crown Bioscience Inc.

Jing Zhang

Minhua Chen

Wenbo Jin

Jian Li

Jianfei Wang

Long Zhang

Shuhui Chen

Yang Zhang

Sheng Guo

Qizhi Yang

Zhigang Xu

Guanlong Huang

Aiping Shi

Peilin Dou

Guangyu Du

Jixian Li

Zhu Mei

Chenggang He

Xia Chen

Jiahui Gu

Haiyan Zhou

Jian Sun

Xinghua Shi

Wubin Qian

Kefeng Liu

Wanchao Zhang

Jinying Ning

Siming Zou

Disclosed is an underwater laying device for offshore oil and gas pipelines. By using a steel cuboid as the main body, a first mud-plowing rake, a first mud-plowing hoe, a second mud-plowing rake, a second mud-plowing hoe, and a mud delivery plate are disposed on the lower surface of the cuboid main body. Further, by cooperation of a mud collection hood and an elongated pipeline-delivery cylinder, and according to structural characteristics of traditional farming tools, submarine trenching, pipeline laying, and pipeline burying can be successively performed and all implemented by the device of the present invention. Further disclosed is a pipeline laying method of the device of the present invention. The device of the present invention has a simple structure, and overcomes the structural complexity of the conventional underwater robot on the premise of achieving the function requirements, thus greatly reducing the manufacturing cost and being mass-producible.

Underwater laying device for offshore oil and gas pipelines and laying method thereof

The present disclosure provides a method for refining styrene by using falling film reboilers and heat pump technology to provide a heat source required by a separation column. According to the method, high-concentration gas-phase ethylbenzene separated from a top of a low pressure ethylbenzene/styrene column is directly pressurized through a compressor, or a heat pump working medium is gasified using the high-concentration gas-phase ethylbenzene separated from the top of the low pressure ethylbenzene/styrene column, and the gasified heat pump working medium is pressurized. The directly pressurized high-concentration gas-phase ethylbenzene or the indirectly gasified and pressurized high-concentration gas-phase ethylbenzene is fed into the falling film reboiler with low heat transfer temperature difference requirement to serve as a heat source of a pre-separation column and/or a styrene product column in a styrene separation process.

Method for refining styrene by using combined falling film reboilers and heat pump technology to provide heat source of separation column

A pharmaceutical composition having a hypoglycemic effect, comprising: a GLP-1 receptor agonist, and a composition for promoting small-intestinal absorption; wherein the composition for promoting small-intestinal absorption comprises sodium lauryl sulfate, carbomer, chitosan, and sodium citrate. The composition for promoting small intestinal absorption according to the present invention may be prepared into a composite adjuvant, which, when combined with a GLP-1 agonist, can improve the absorption of this active ingredient in the small intestine and the like.

Hypoglycemic pharmaceutical composition

A grapevine soil-cleaning device and engineering machinery installed with the soil-cleaning device, comprising an air blower (), an air vent direction reversal device, a soil-retaining device, an angular sensor () and a controller (). The controller () is connected to the air blower (), the angular sensor (), the air vent direction reversal device and the soil-retaining device respectively. The present device achieves non-contact soil cleaning by blowing air, and has the advantages of no harmful impact on buds and branches, one-time cleaning, and highly efficient soil cleaning. The air vent direction reversal device may achieve a consistent air-blowing direction when the grapevine soil-cleaning device moves among rows of the grapevine. The soil-retaining device may hold back the blown soil and reduce the displacement distance of the blown soil. An auxiliary air pipe is provided below a main air pipe to assist soil-cleaning operations and avoid generating pits on a ridge due to concentrated wind power of the main air pipe. The air vent direction reversal, adjustment of the air power of the air blower and automated direction reversal of the soil-retaining device when moving among ridges are achieved by using the angular sensor () and the controller (), thus achieving a high level of technological intelligence.

Grapevine soil-cleaning device and engineering machinery provided installed with soil-cleaning device

A composition comprising: a surfactant, an acrylic polymer, chitin or its derivatives, and a metal ion chelating agent. Studies have shown that the composition can promote absorption of effective ingredients in the small intestine and improve their bioavailability.

Composition for improving bioavailability of drugs

The present disclosure relates to novel crystalline forms of tafamidis (hereinafter referred to as compound I) and processes for preparation thereof. The present disclosure also relates to pharmaceutical composition containing the novel crystalline forms, use of the novel crystalline forms for preparing drugs treating disease caused by transthyretin-mediated amyloidosis. The crystalline forms of tafamidis of the present disclosure have one or more improved properties compared with crystalline forms of prior art and have significant value for future drug optimization and development.

Crystal form of tafamidis and preparation method therefor and use thereof

Crystalline forms of upadacitinib and processes for preparation thereof are disclosed. The present disclosure also relates to pharmaceutical compositions containing the upadacitinib crystalline forms, use of the upadacitinib crystalline forms for preparing JAK1 inhibitor drugs, and use of the upadacitinib crystalline forms for preparing drugs treating rheumatoid arthritis, Crohn's disease, ulcerative colitis, atopic dermatitis and psoriatic arthritis. The crystalline forms of upadacitinib provided by the present disclosure have one or more improved properties compared with prior arts and have significant values for future drug optimization and development. 

Crystal form of upadacitinib, preparation method therefor, and use thereof

A method for predicting the responsiveness of a cancer cell to an MEK inhibitor, comprising detecting the presence of at least one mutation in one or more genes selected from the group consisting of ADAM12, COL14A1, TNN, and TP53, in the cancer cell, by contacting a nucleic acid sample derived from the cancer cell with at least one oligonucleotide which allows specific detection of the mutation; wherein presence of mutation in ADAM12, COL14A1, TNN, TP53 and/or any combination thereof is indicative of decreased responsiveness of the cancer cell to the ERK inhibitor.

Methods for determining responsiveness to MEK/ERK inhibitors

Disclosed are two axially chiral isomers and pharmaceutically available salts thereof, preparation method therefor, and pharmaceutical use of the two axially chiral isomers or pharmaceutical compositions thereof.

Axially chiral isomers, and preparation methods therefor and pharmaceutical uses thereof

Growing community of inventors

Jiangsu, China

Jing Zhang