Hoffmann-la Roche Inc.

Allelix Neuroscience Inc.

Riboscience LLC

F. Hoffmann-la Roche Ag

Jing Zhang

Zhuming Zhang

Qingjie Ding

Nan Jiang

Stanley Charles Bell

Xin-Jie Chu

Laurence A Borden

Vassil Iliya Ognyanov

Song Yang

Elbert Chin

Jin-Jun Liu

David Joseph Bartkovitz

Robert James Weikert

Li Chen

Sung-Sau So

Jean-Marc Plancher

Mark Smith

Shawn David Erickson

Francisco Xavier Talamas

Kin-Chun Thomas Luk

Tina Morgan Ross

Weiya Yun

Eric Mertz

Buelent Kocer

Bradford Graves

Stephen Deems Gabriel

Zhi Chen

Qiang Zhang

Joseph Anthony Bilotta

Feng Chi

Bradford James Graves

The present invention relates to the use of 3'-fluoro, 4&#x2032;-azido nucleoside phosphoramidate prodrug derivatives of formula I wherein the symbols are as defined in the specification, to pharmaceutically acceptable salts thereof, and to pharmaceutical compositions containing such compounds for the treatment of HCV.

4'-azido, 3&#x2032;-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication

The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection. 

Antiviral compounds

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient. 

Inhibitors of bruton's tyrosine kinase

The present disclosure relates to compounds of Formula (I): Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of using the compounds of Formula (I) and/or compositions comprising the compounds of Formula (I) for the treatment of HCV. 

2', 4&#x2032;-difluoro-2&#x2032;-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

There are provided compounds of the formula wherein X, Y, R, R, R, R, R, R, Rand Rare as described hereinand enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

Substituted pyrrolidine-2-carboxamides

There is provided a compound of the formula 

Substituted spiroindolinones

There are provided compounds of the formula or a pharmaceutically acceptable salt or ester thereof wherein X, Y, R, Rare as herein described. The compounds have utility as antiproliferative agents, especially, as anticancer agents.

Spiroindolinone derivatives

There are provided compounds of the formula wherein X, Y and Rto Rare as described herein and the enantiomers and pharmaceutically acceptable salts and esters thereof which compounds have anticancer activity.

Spiroindolinone pyrrolidines

There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereof The compounds are useful as anticancer agents.

There are provided compounds of the formula wherein X, Y and Rto Rare described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

There is provided compounds of the formula wherein R, V, W, X, Y, Q and n are as described. The compounds exhibit activity as anticancer agents.

Oxindole derivatives

The invention describes compounds of the general formula I or the pharmaceutically acceptable salts thereof,wherein R, R, Rand X are herein described,a process for their manufacture, medicaments containing them as well as the use of these compounds as pharmaceutically active agents. The compounds show activity as antiproliferative agents and may be especially useful for the treatment of cancer.

The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:or a pharmaceutically acceptable salt thereof.

Pharmaceutical for treatment of neurological and neuropsychiatric disorders

The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula:

The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the following formulas I and II: ##STR1## or a pharmaceutically acceptable salt thereof.

Growing community of inventors

Parsippany, NJ, United States of America

Jing Zhang