Shanghai Jiaotong University

Honeywell International Inc.

Merck Patent Gmbh

Cadence Design Systems, Inc.

East China University of Science and Technology

Medshine Discovery Inc.

Micron Technology Incorporated

Cisco Technology, Inc.

Chinese Academy of Sciences

Inventec Appliances Corporation

Shanghai Microport Medical (group) Co., Ltd.

Relay Therapeutics, Inc.

Wuxi Ea Medical Instruments Technologies Limited

Shanghai Microport Cardioflow Medtech Co., Ltd.

Saic Motor Corporation Limited

Jing Wang

Peng Yuan

Liejia Qian

Guoqiang Xie

Jingui Ma

Haiying He

Zhigan Jiang

Weiwen Zou

Shaofu Xu

Shuhui Chen

Wei Wang

Qiang Li

Yongzhi Wang

Chao Li

Qiyi Luo

Hua Jiang

Pablo Bandera

Xuegang Zeng

Lei Han

Yaxun Yang

Junsheng Chen

Jianhua Xia

Chen Zhang

Jian Li

Yong Wang

Xiao Xun Zhang

Jun Hui Liu

Wei Lu Chu

Alexander M Taylor

Xiaoyan Zhang

Jianping Chen

David Ho

Guoming Chen

Beverly Lubit

Hui Zhou

André Lescarbeau

Sven Christian Laut

Jianqing Xu

Kenneth Robert Willis

Yuan Fang

Yong-Ping Zheng

Ping Zhao

Yu Li

Bingjie Zhou

Minyi Guo

Changsheng Liu

Jason Dai

Yonghui Zhang

Juan Hou

Peter Yang

Haojin Zhu

Pengyu Wang

Jianwei Zhu

Yueqing Xie

Hongyan Jiang

Yahong Kang

Zhen Mu

Daolong Tang

Hui Qi

Liping Zhao

Jiayuan Fang

Jing Liang

Ling Zhu

Biao Yu

Kathy Xia Ke

Kunmin Lai

Yang Feng

Xiaolin Liu

Jian Xu

Lixia Han

Min Guo

Menghui Zhang

Jiangchao Qian

Yanyan Zhang

Dianyuan Fan

Kezhou Li

Wei-Jun Pan

Lingyan Zhu

Peng Shao

Feng Miao

Chang-Suk Choi

Hee-Kyu Lee

Jinyang Guo

Chuanming Shao

Huifang Zong

Kai Dai

Qinghao Zhang

Lihong Lan

Shunshu Deng

Guilong Li

Zhiwei Liang

Gaodeng Lian

Raghu Sreeramaneni

Jiaoming Dong

Yemeng Chen

Dakai Chen

Pengfei Fang

Wanli Xing

Xiaoyi Zhang

Xiyong Xu

Disclosed is a stem cell generator for the generation of organoids after the development of biological materials loaded with active substances which are implanted into an animal or a human body. The active substances are mesenchymal stem cells, bone morphogenetic protein-2 or bone morphogenesis protein-7, other growth factors/polypeptides or growth factors/polypeptide combinations having the ability of inducing bone regeneration, or combinations thereof. The stem cell generator contains various types of blood cells and hematopoietic progenitor/stem cells having complete functions. The produced stem cells are used for treating hematopoietic damage, and can treat bone marrow failure and leukemia caused by radiotherapy/chemotherapy.

Use of stem cells produced by stem cell generator in treatment of hematopoietic damage

The present invention relates to liquid-crystal (LC) media as defined in claim, having negative dielectric anisotropy and to the use thereof for optical, electro-optical and electronic purposes, in particular in LC displays.

Liquid-crystal medium

A polypeptide composition, and methods of making the same, may include a first polypeptide and a second polypeptide, wherein the first polypeptide comprise a first toxin fragment and a first intein fragment, the second polypeptide comprise a second toxin fragment and a second intein fragment, the first polypeptide is different from the second polypeptide; the first toxin fragment and the second toxin fragment are non-biotoxic; the first polypeptide and the second polypeptide may make the first toxin fragment and the second toxin fragment into biotoxic toxins by an interaction of the first intein fragment and the second intein fragment. Kits may include such first and second polypeptides, and such compositions and kits may be used in treating tumors.

Polypeptide composition

Provided is a polypeptide combination, a targeting component thereof comprising a shielding peptide, a cleavable part, an antigen-binding part and a first intein fragment, the shielding peptide and the antigen-binding part being connected by means of the cleavable part, and the antigen-binding part being directly or indirectly connected to the first intein fragment; a toxin component thereof comprises a second intein fragment and a toxin, and the second intein fragment is directly or indirectly connected to the toxin; the targeting component and the toxin component form an immunoconjugate by means of the interactive action between the first intein fragment and the second intein fragment; in the immunoconjugate, the shielding peptide and the antigen-binding part are connected by means of the cleavable part, and the antigen-binding part is connected to the toxin. Also provided are a preparation method and a pharmaceutical use for the polypeptide combination.

Polypeptide combination used for tumour immunotherapy, and preparation method therefor

An adaptive, large graph-oriented unified memory management method is proposed; according to the order of priorities of different types of graph data structure in a graph computing application, whether the current GPU memory is full is sequentially determined by means of GPU memory checking; whether the size of current graph data exceeds the available memory capacity of the GPU is determined by means of data overflow checking; and then a unified memory management policy is configured; the method uses different graph algorithms based on the characteristics of graph data structure and the size of the available GPU memory; the method can significantly improve the performance of processing large graphs, which exceed the video memory capacity under a unified memory architecture, including improving GPU bandwidth utilization, reducing the number of page faults and the overhead of processing page faults, and speeding up the execution of graph computing programs.

Adaptive unified memory management method and system for large-scale graphs

Disclosed are crystal form A and crystal form B of a compound represented by formula (I), and application thereof in the preparation of medicaments for treating HBV-related diseases.

Crystal form of tri-cycle compound and application thereof

Systems, methods, and apparatuses relating to interlocking transistor active regions are disclosed. An apparatus includes a gate including electrically conductive material and an active material including a doped semiconductor material. A portion of the active material overlapped by the gate has an at least substantially triangular shape. An apparatus includes a plurality of active materials. Each active material includes tapered ends and a plurality of gates. The plurality of active materials is arranged in an interlocking pattern with at least some tapered ends of the active materials interlocking with at least some others of the tapered ends. The plurality of gates overlaps the interlocked tapered ends of the plurality of active materials.

Fuse array layout pattern and related apparatuses, systems, and methods

A high-speed and low-voltage electro-optical modulator based on a lithium niobate-silicon wafer. A silicon wafer is located above a lithium niobate wafer; a lithium niobate-silicon hybrid waveguide is formed by etching a silicon waveguide; and the power of light waves is differently distributed in the lithium niobate-silicon hybrid waveguide by changing the structure of the silicon waveguide. When higher power is distributed in the silicon waveguide, the high-speed and low-voltage electro-optical modulator is suitable for realizing a compact wave splitting function, a wave combining function and a thermo-optical modulation function; and when higher power is distributed in the lithium niobate waveguide, the high-speed and low-voltage electro-optical modulator is suitable for realizing a high-speed and low-voltage electro-optical modulation function. The present invention takes advantage of the lithium niobate and silicon material platforms respectively, and is suitable for high-speed and low-voltage electro-optical modulation.

High-speed and low-voltage electro-optical modulator based on lithium niobate-silicon wafer

The disclosure is in part directed to crystalline forms of (R)-1′-(3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4′-piperidin]-3-amine, its salt, and variants thereof.

SHP2 phosphatase inhibitors and methods of making and using the same

A graph sampling and random walk acceleration method and system based on GPU. The graph data is read from the storage medium through the CPU and converted into CSR format and then output to the GPU. The GPU works based on the defined working mode: Real-time generation of alias table and sampling; or offline judgment whether there is a pre-generated alias table and sampling, which executes the alias method efficiently and in parallel, and can significantly improve the performance of graph data processing on the same hardware platform, including improving the sampling throughput and reducing the overall running time.

Graph sampling and random walk acceleration method and system on GPU

A monolithically integrated optical analog-to-digital conversion system based on a lithium niobate-silicon wafer, and a method for manufacturing the same, wherein a novel wafer (lithium niobate-silicon wafer) is used to implement the monolithically integrated optical analog-to-digital conversion system having multiple photonic devices, including an electro-optical modulator array, a tunable delay line array, an electronic circuit, and the like. As a result, multiple devices are manufactured on one chip, and the performance advantages and the stability of the system are guaranteed. Moreover, the present invention provides a CMOS-compatible method for manufacturing the system, so that the monolithically integrated optical analog-to-digital conversion system based on the lithium niobate-silicon wafer can be implemented on platforms of most chip manufacturers.

Monolithically integrated optical analog-to-digital conversion system based on lithium niobate-silicon wafer and method for manufacturing the same

A liquid-crystal (LC) media having a negative dielectric anisotropy containing a compound of formula I and the use of the LC media for optical, electro-optical and electronic purposes, in particular in energy-efficient LC displays, especially in IPS, FFS, VA or PS-VA displays.

The present disclosure relates to a computer-implemented method for use in an electronic design. Embodiments may include performing, using a processor, a simulation of a multi-layered electronic structure and extracting a circuit model of the multi-layered electronic structure, wherein the circuit model includes at least two plates. Embodiments may also include extracting one or more parasitic parameters of at least one via associated with the circuit model and calculating a coupling coefficient associated with a controlled source of the circuit model. Embodiments may further include extracting a transmission line mode from the circuit model and linking the circuit model, at least one via, and the transmission line mode to an external circuit to generate a modeled system. Embodiments may also include solving the modeled system using a modified nodal analysis.

Systems and methods for modeling interactions of power and signals in a multi-layered electronic structure

The present disclosure provides, in part, a priming and boosting vector-based platform to develop vaccines against pathogens that is tailored to elicit a broad T cell response targeting conserved viral epitopes. The universal vaccines are prepared against an immunogen of an infectious pathogenic organism selected from a virus, a bacteria, a fungus or a protozoan comprising at least one ribonucleic acid (RNA) polynucleotide comprising an open reading frame encoding at least one polypeptide antigen or an immunogenic fragment thereof, wherein the polypeptide antigen, or the immunogenic fragment thereof, comprises a conserved internal protein that is enriched in CD8+ T cell recognition antigens. The effectiveness of the priming and boosting platform is tested in a humanized mouse model comprising a fully functional human immune system.

Universal vaccines against immunogens of pathogenic organisms that provide organism-specific and cross-group protection

The present invention relates to a method for inducing amplification of human type I NKT cells in vitro using a 'specific stimulant+staged cytokine' mode, which consists of two culture stages, wherein the first culture stage focuses on specific amplification of the number of the type I NKT cells, in which a specific stimulant &#x3b1;-GalCer is used to advantageously amplify the type I NKT cells and &#x3b1;-GalCer-loaded CD1d-expressing cells are used to stimulate continuous proliferation of the type I NKT cells while adding cytokines IL-2 and IL-7 to assist growth of the type I NKT cells; and the second culture stage is to synchronously perform amplification of the number of the type I NKT cells and guide directed function differentiation, in which CD1d-expressing cells incubated with &#x3b1;-GalCer continue to stimulate proliferation of the type I NKT cells while adding IL-2, IL-7 and IL-15 to assist amplification of the type I NKT cells and guide differentiation, and IL-12 is added to the culture system 1-2 days before the end of culture to guide further directed differentiation of the type I NKT cells and enhance their killing activity. The method of the present invention is simple to operate, can greatly amplify the type I NKT cells in vitro while improving the killing activity of the amplification products, and is suitable for large-scale production.

Method for inducing amplification of type I NKT cells in vitro

Growing community of inventors

Shanghai, China

Jing Wang