Applera Corporation

Applied Biosystems, LLC

Spectralane, Inc.

Jing Tian

Sam L Woo

Ronald J Graham

Gary Leonard Woods

Keith A Sigg

Donald A Pitt

Ron Graham

The present invention relates generally to nucleobase polymer functionalizing reagents, to mobility-modified sequence-specific nucleobase polymers, to compositions comprising a plurality of mobility-modified sequence-specific nucleobase polymers, and to the use of such polymers and compositions in a variety of assays, such as, for example, for the detection of a plurality of selected nucleotide sequences within one or more target nucleic acids. The mobility-modifying polymers of the present invention include phosphoramidite reagents which can be joined to other mobility-modifying monomers and to sequence-specific oligonucleobase polymers via uncharged phosphate triester linkages. Addition of the mobility-modifying phosphoramidite reagents of the present invention to oligonucleobase polymers results in unexpectedly large effects the mobility of those modified oligonucleobase polymers, especially upon capillary electrophoresis in non-sieving media.

Mobility-modified nucleobase polymers and methods of using same

An optical amplifier suitable for use in optical communication systems such as for telecommunications or cable television provides, for purposes of wavelength division multiplexed communications, the ability to amplify optical signals in both the C band, L band, and S band using conventional EDFA amplifiers. The S band, normally not amplifiable by EDFAs, here is amplified by converting the S band signal to a C band optical signal, providing optical amplification by an EDFA, then reconverting the amplified C band optical signal back to the S band in the same or a subsequent amplifier stage. The wavelength converters are, for instance, periodically poled lithium niobate devices using three-wave mixing, and employing difference frequency generation techniques.

Optical amplifier using wavelength converter

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Jing Tian