Shanghai Jiaotong University

Gm Global Technolgoy Operations, Inc.

Gracell Biotechnologies (shanghai) Co., Ltd.

Shanghai Well-sun Precision Tools Co., Ltd.

Shanghai Yisi Medical Technology Co., Ltd.

Suzhou Gracell Biotechnologies Co., Ltd.

Shanghai Well-sun Procision Tool Co., Ltd.

Jing Sun

Jishun Wang

Mengyi Wang

Dalong Gao

Feng Gao

Ningjian Huang

Liping Liu

Qiao Sun

Ren Liu

Xianbao Chen

Chunhui Yang

Zhongdong Shi

Wei Cao

Lei Liu

Lu Wang

Xiliang Zhang

Xinxin Wang

Anhua Li

Lin He

Fan Zhao

Yiling Chen

Xinliang Zhang

Jihong Huang

Fujun Wang

Minhua Zheng

Bo Feng

Junjun Ma

Yanan Lu

Shuyi Qiu

Sun Chen

Kai Bai

Tao Jin

Huaibing Liu

Caiyun Yang

Nianqi Wan

Shengying Qin

Songbai Cai

Kun Sun

Honglin Nie

The present disclosure relates to an engineered immune cell and use thereof. The present disclosure provides an engineered immune cell comprising a CAR or engineered TCR, which CAR or engineered TCR can comprise a first antigen binding domain and a second antigen binding domain. The engineered immune cells of the present disclosure, when administered into a subject, can inhibit the host immune cells such as T cells and/or NK cells and enhance the survival and persistence of the engineered immune cells in vivo, thereby exhibiting more effective tumor killing activity.

Compositions and methods for T cell engineering

Accessory for nail polisher

A use of a detection reagent for a microRNA (miRNA) marker miR-143-3p in the preparation of a product for evaluating a therapeutic effect of olanzapine in the treatment of schizophrenia (SZ) and a kit are provided. An expression level of miR-143-3p can be detected to determine a therapeutic effect of olanzapine in the treatment of SZ of a patient, and can be used as a detection or treatment index in clinical practice, which provides a theoretical basis for the mechanism research of SZ and the clinical application.

Use of microRNA (miRNA) marker in preparation of product for evaluating therapeutic effect of olanzapine in treatment of schizophrenia (SZ) and kit

Provided are a universal chimeric antigen receptor (CAR) T cell and preparation method and application thereof. The binding of the cell HLA-A/HLA-B to the TCR is inhibited; the TCR gene expression is silenced; the invention may be used for allogeneic tumor treatment and does not cause GVHD and HVG reaction during allogeneic infusion, and thus improves the survival and antineoplastic effect of allogeneic CAR-T cells in the recipient.

Universal chimeric antigen receptor T-cell preparation technique

A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.

Preparation method of absorbable vascular stent coating for angiostenosis in infant

A robotic system includes a support structure, a motor mount assembly, first and second parallel chains, a serial translation assembly, a sensor and a control module. The motor mount assembly includes rotary motors, where the rotary motors include a first rotary motor and a second rotary motor. The first and second parallel chains are connected to the movable platform, the rotary motors and the motor mount assembly. The serial translation assembly is connected to the supporting structure and the motor mount assembly and includes a linear actuator and a third rotary motor. The sensor is connected to the movable platform and detects force applied by a human operator on the movable platform and generates a signal indicative of the force applied. The control module controls the rotary motors and the third rotary motor based on the signal to assist the human operator in moving the movable platform.

Three degree-of-freedom robotic systems for automatic and/or collaborative planar fastening operations

A robotic system includes a support structure, a platform, a center serial chain, outer serial chains, motors, a sensor, and a control module. The center serial chain connects a center of the platform to the support structure and includes first joints connected to a linear sliding shaft. The outer serial chains are disposed radially outward of the center serial chain. Each of the outer serial chains includes second joints connecting a bar to the platform and the supporting structure. The motors are connected to the outer serial chains. The sensor is connected to the platform and detects at least one of force or torque applied by a human operator on the platform and generates a signal indicative thereof. The control module controls the motors based on the signal to assist the human operator in at least one of moving or rotating the platform.

Six degree-of-freedom and three degree-of-freedom robotic systems for automatic and/or collaborative fastening operations

A five-in-one polishing head includes a blade portion and a handle portion. The blade portion is shaped like a cone having a concave or planar top end. Angle teeth, thin teeth, medium-thin teeth, and thick teeth are sequentially distributed in a conical polishing head according to the tooth density. The angle teeth are located at the top of the conical polishing head in a circle. The thick teeth are located at the end of the blade portion. The center of the end of the blade portion is axially welded and fixed to one end of the handle portion. The conical polishing head is provided with regularly distributed straight lines or oblique lines on a surface from the angle teeth to the thick teeth. The shape of a right-handed groove on the surface is inverted trapezoidal, and the shape of a left-handed groove is triangular.

Five-in-one polishing head

Grinder bistrique

An improved surgical apparatus actuator includes a nail bin assembly (), a nail anvil assembly () connecting with the nail bin assembly (), and a drive assembly () controlling the nail bin assembly () and the nail anvil assembly () to convert between opening and closing conditions. The nail anvil assembly () includes a nail anvil plate () and a nail anvil seat (), wherein the nail anvil plate () is provided on an inner side () of the nail anvil seat (), the nail anvil seat () has the structure, material and processing technology capable of providing high anti-bending performance, the nail anvil plate () is cold-punched from a thinner stainless steel sheet. Therefore, the processing difficulty of the components is reduced, and meanwhile, the ability of the actuator chuck to resist bending deformation is improved.

Surgical apparatus actuator

Growing community of inventors

Shanghai, China

Jing Sun