R.p.scherer Technologies, Inc.

Catalent Australia Pty Ltd.

Jing Lin

Hung Truong

Humera Ahmad

Jonathan Do

Ashish Patel

Enteric softgel capsules comprise a fill material and an enteric shell composition, characterized in that the enteric nature of the capsules may be achieved without an enteric coating or added conventional enteric polymers.

Enteric softgel capsules

The invention includes dosage formulations, dosage forms and related methods for providing oral dosage forms of low solubility active ingredients such as coenzyme Q10. The present invention includes a Self-Microemulsifying Drug Delivery System (SMEDDS) in the form of a self-microemulsifying mixture that comprises a combination of a hydrophilic surfactant and a lipophilic co-surfactant (forming a surfactant pair). The preferred surfactant pair comprises a hydrophilic surfactant and a lipophilic co-surfactant with respective HLB (Hydrophile-Lipophile Balance) values of more than 12 and less than 8 respectively. The systems also contain at least one lipophilic solvent. The formulations exhibited excellent dissolution properties and storage stability.

Self-microemulsifying dosage forms of low solubility active ingredients such as co-enzyme Q10

The invention herein relates to a pharmaceutical composition containing loratadine and derivatives thereof which is suitable for use in soft capsule dosage forms. A pharmaceutical composition according to the invention comprises loratadine and derivatives thereof in a pharmaceutically effective amount; and a solvent system comprising a mixture of medium chain fatty acids. The loratadine compositions exhibit good solubility and storage stability while maintaining bioavailability of the drug. The compositions also permit high concentrations of solubilized loratadine per total fill volume and thereby permit the use of smaller capsules to deliver the same dosage of drug.

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Mulgrave, Australia

Jing Lin